Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1969

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

The influence of oral contraceptives with and without an ovulation

suppressant action on thyroid function tests: preliminary observations on

differences in insulin response to glucose.

AUTHORS

Taft P; Winikoff D; Taylor K; Page D; Brittingham LC

SOURCE

In: Christie, G.A. and Moore-Robinson, M., eds. Chlormadinone acetate: a new

departure in oral contraception. (Proceedings of a symposium, Gonville and

Caius College, Cambridge, September 14, 1968) Amsterdam, Excerpta Medica,

ABSTRACT

In 12 normal patients it was observed that after only 1 cycle of administration of continuous or sequential ovulation

suppressant therapy there was a movement of protein bound iodine (PBI) levels toward the toxic range and tri-

iodothyronine resin uptake (RU) and electrophoretic index (EI) toward the subthyroid range, though not always

beyond, the normal range. In 52 patients taking a variety of ovulation suppressants over a period of 1-5 years the PBI

values ranged from 4.8 to 9.1 mcg/100 ml. RU ranged from 54.8% to 90.4% and the EI from 70.7% TO 84%. In only 2

of these patients were all 3 of these parameters normal. In the group of 52 patients, 11 discontinued the medication

to allow thyroid tests. All values moved toward normal. Fluctuations in all parameters were observed in individual

patients during therapy and effects persisted for 8 weeks after treatment. Higher estrogen content of drugs and longer

duration of therapy caused increased changes. Thyroxine binding was increased under the influence of oral

ovulation inhibitors. Clinical evidence of thyroid functional change was not observed. However, in other cases,

thyrotoxicosis has been clinically evident after 2 or 3 cycles of combined estrogen-progestogen therapy. Also

subthyroid patients taking these drugs have improved with small doses of thyroxine. In another study 8 young people

and 23 geriatric patients were given various progestogens for 2 or 3 cycles and estrogen alone or combined with the

progestogen for 1 or 2 more cycles. Blood samples were taken at the last day of each cycle. Elderly patients

responded the same as young people with changes in all parameters in 1 cycle. Progestogens, except

norethynodrel, were without effect. HOWEVER, combined, changes were noted and the effects of norethynodrel were

increased. An absence of any synergistic effect of estrogens by progestogens was shown in 3 experiments. In 8

other patients treated with low dosage chlormadinone acetate, .5 mg daily, over long peroids, thyroid function tests

remained in the normal range. Oral glucose tolerance tests in patients taking ovulation suppressants or

chlormadinone acetate suggest that the exaggerated insulin response to glucose seen with the suppressants doses

not occur with chlormadinone acetate. (PubHealth.info Document ID: CONT9T 14-06)

PubHealth.info NOTE: The author(s) of this article titled, "The influence of oral contraceptives with and without an

ovulation suppressant action on thyroid function tests: preliminary observations on differences in insulin response to

glucose.", is(are) Taft P; Winikoff D; Taylor K; Page D; Brittingham LC. The source of this article is "In: Christie,

G.A. and Moore-Robinson, M., eds. Chlormadinone acetate: a new departure in oral contraception. (Proceedings of a

symposium, Gonville and Caius College, Cambridge, September 14, 1968) Amsterdam, Excerpta Medica, February

1969. p. 60-72". This article was published in 1969 in English language(s). (PubHealth.info® Document ID: CONT9T

14-06. All rights reserved with PubHealth.info) PIN: 40014

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