Contraception (Birth Control) and Family Planning PubHealthInfo

[PubHealth.info Homepage] [Category Homepage] [Disclaimer/Copyrights] [Feedback]

Thank you for your kind visit to PubHealth.info®, an information portal created in technical collaboration with PakMed Biomedical Solutions * * * PubHealth.info® presents hundreds of thousands of informative Web pages on a variety of public health issues / issues * * * An ultimate source of information for teachers, students and research workers who need to find information on various public health issues, like population planning, contraception, HIV AIDS, STDs, maternal and child health, communicable and non-communicable disease, etc. * * * PubHealth.info® regularly updates the repository of these hundreds of thousands of informative Web pages * * * PubHealth.info® is one of the world's largest repositories and information portals with online Web pages on public health issues particularly those pertaining to developing countries!

PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1968

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Functional and morphological liver changes in women taking oral

contraceptives.

AUTHORS

Pihl E; Rais O; Zeuchner E

SOURCE

Acta Chirurgica Scandinavica. 1968;1334:639-650.

ABSTRACT

In view of the vast importance of contraceptives and the frequency of unwanted side-effects, particularly jaundice and

abdominal symptoms, the authors untertook to relate clinical findings with ultrastructural liver morphology in women

taking such pills and also having gallstones and to compare the results with those from a control group of women

with only cholelithiasis. A group of 16 women, aged 18-35 years, taking Anovlar (Norethisterone 4 mg,

ethinylestradiol .05 mg/pill), Coluten (norethistirone 2 mg, mestranol .1 mg/pill) or Linoral (ethinyl-estradiol 10 mg/pill)

were studied. 5 of these women had never been pregnant. In 11 of these women gallstones were diagnosed by X-

ray. 1 patient had had a venous' thrombosis of a leg. 1 patient had had toxemia during 2 previous pregnancies. In

10 patients cholecystectomy with cholangiography and liver biopsy were performed in a quiet stage of the gallbadder

disease. In 1 other patient cholecystectomy was done because of increasing jaundice. Needle biopsy of the liver

was taken in those not operated on. The control group consisted of 11 female and 1 male patients, aged 21-64

years, who were operated on for gallstones. Amost all of the women taking contraceptives had elevated

transaminases. Primary cell damage was also indicated by the SGPT/SGOT which is generally said to be above 1

in hepatitis and toxic liver damage and about 1 in extrahepatic cholastasis. Of the 16 women taking contraceptive

pills, this quotient was above 1 in 13. No sign of hepatitis were present. Canalicular cholastasis is suggested by

the increase bromsulphatalein retention and by the elevated alkaline phosphatases in women taking contraceptives

and also have gallstones. Little difference was noted between liver changes of the 2 groups as seen by the light and

electron microscopes. Impaired liver function morphological changes were usually consistent. 2 cases with normal

laboratory data in spite of morphological changes may have had some hepatic impairment during a more active

acute stage. There was no indication of irreversible changes such as altered lobular architecture, fibrosis or chronic

inflammation. The authors conclude that ontraceotive steriods may have a help to a toxic effect, conceivably of a

hepatocellular type, and a secondary hepatocanicular effect. Some of the findings favor a correlation between oral

contraceptives and biliary concrements. (PubHealth.info Document ID: CONT9T 1063-06)

PubHealth.info NOTE: The author(s) of this article titled, "Functional and morphological liver changes in women

taking oral contraceptives.", is(are) Pihl E; Rais O; Zeuchner E. The source of this article is "Acta Chirurgica

Scandinavica. 1968;1334:639-650.". This article was published in 1968 in English language(s). (PubHealth.info®

Document ID: CONT9T 1063-06. All rights reserved with PubHealth.info) PIN: 41063

This page is optimized to be viewed by Java script enabled Microsoft® Internet Explorer 6 or later version, at screen resolution of 800 by 600 pixels.