Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1968

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Fine structural effects of intrauterine contraceptives on the human

endometrium,.

AUTHORS

Wynn RM

SOURCE

Fertility and Sterility 19(6): 867-882. 1968.

ABSTRACT

Of 198 endometrial biopsies performed on 82 women with Lippes loops in situ for 6 weeks to 40 months, 124 were

proliferative and 74 were secretory. Samples were obtained from immediately beneath the device, between the loops,

and from areas remote from the device. Specimens of basal endometrium, lower segment, or endocervix were

excluded. Control tissue was obtained before insertion of the device. Slides were prepared for electron microscopy.

No consistent, generalized pathologic change was observed in either proliferative or secretory endometria. The

stroma immediately beneath the loop appeared compressed and fibrotic throughout the cycle. Proliferative

epithelium maintained the normal pattern of juxtaposed light and dark (electron-dense) cells, mitotic activity, and

distribution of microvilli and cilia. No progression of epithelial ultrastructural differences occurrred after their first

appearance in the second month after IUD insertion. Precocious changes in epithelial ultrastructure included 1) the

appearance of a nucleolar channel system, normally considered indicative of ovulation or exogenously administered

hormones, in 15-29% of endometria judged to be preovulatory; 2) numerous large mitochondria, usually associated

with the postovulatory phase, in the late-proliferative endometrium and occasionally as early as in the

midproliferative; and 3) the development of confluent fields of glycogen at the end of the proliferative phase, a few

days earlier than in controls. The premenstrual endometrium resembled the contrl of this stage; scarcity of microvilli

and other characteristic ultrastructural traits of regression were noted. Ultrastructural changes in the proliferative

stroma were observed first about 1 day preovulatory, when the cytoplasm appeared better differentiated than in the

controls. The stromal cells were highly differentiated at the end of the first postovulatory week; the cytoplasmic

complexity at Days 19 or 20 often resembled that of Day 25 controls. Premature and asynchronous development of

the endometrium may affect the correlation with ovular development which is a prerequisite for normal implantation.

Since the IUD creates an unfavorable environment for blastocystic attachment, but does not dislodge the implanted

ovum, its action is considered contraceptive rather than abortifacient in the usual sense. (PubHealth.info Document

ID: CONT9T 1059-06)

PubHealth.info NOTE: The author(s) of this article titled, "Fine structural effects of intrauterine contraceptives on the

human endometrium,.", is(are) Wynn RM. The source of this article is "Fertility and Sterility 19(6): 867-882. 1968.".

This article was published in 1968 in English language(s). (PubHealth.info® Document ID: CONT9T 1059-06. All

rights reserved with PubHealth.info) PIN: 41059

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