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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.





YEAR: 1968




CATEGORY: Contraception (Birth Control) and Family Planning



TITLE



The effects of oral contraceptives on the endometrium. I. Blood vessels.



AUTHORS

Blaustein A; Shenker L; Post RC


SOURCE

International Journal of Fertility. 1968 Oct-Dec;13(4):466-475.



ABSTRACT

78 endometrial biopsies from 58 patients (ages 21-50 years) taking both sequential and combination oral

contraceptives, and 10 extra-uterine tissues were studied for vascular changes. Of the endometria examined, 31.3%

revealed endothelial hyperplasia in coiled and basilar arteries as well as sinusoids, and 5.1% were so extensive as

to reduce the caliber of the overall lumen. Smooth muscle hyperplasia was evident in 82%, of which 3.4% were

considered extensive. Similar changes were observed in the skin, colon, cervix, ovary and breast tissue, suggesting

that while end organ response is readily detected, the vascular changes are not wholly confined to the uterus. The

incidence was higher in patients on sequential therapy (endothelial hyperplasia in 73%, smooth muscle hyperplasia

in 58%) than in those on combination therapy (endothelial hyperplasia in 48%, smooth muscle hyperplasia in 33%).

There appeared to be no relationship of incidence to duration of therapy, and lesions did not appear to be

progressive. Studies of the endometrium of pregnancy, hyperplasia and polypi revealed similar changes in all

conditions, though rarely to the same degree. Oral contraceptives used for long periods of time could result in thick-

walled vessels and narrowed lumina; the relationship of such alterations to arteriosclerosis remains to be

determined. There is a distinct possibility that endothelial hyperplasia may be related to thromboembolism, since

venous channels and sinusoids show endothelial hyperplasia as well as arteries. (PubHealth.info Document ID:

CONT9T 1007-06)



PubHealth.info NOTE: The author(s) of this article titled, "The effects of oral contraceptives on the endometrium. I.

Blood vessels.", is(are) Blaustein A; Shenker L; Post RC. The source of this article is "International Journal of

Fertility. 1968 Oct-Dec;13(4):466-475.". This article was published in 1968 in English language(s). (PubHealth.info®

Document ID: CONT9T 1007-06. All rights reserved with PubHealth.info) PIN: 41007





 

 

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