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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.





YEAR: 1973




CATEGORY: Contraception (Birth Control) and Family Planning



TITLE



Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated

with oral contraception.



AUTHORS

Adams PW; Rose DP; Folkard J; Wynn V; Seed M; Strong R


SOURCE

Lancet1: 897-904. April 28, 1973.



ABSTRACT

22 women attending the Margaret Pyke Center, London, and suffering from supposed oral contraceptive-related

depression were studied. Symptoms of the depression included pessimism, dissatisfaction, crying, tension, anxiety,

and loss of libido; sleep and appetite disturbances were not included. 11 of the women showed biochemical

evidence of an absolute deficiency of vitamin B6. Age of the women, duration of oral contraceptive usage, and the

progestagen content of the pill did not correlate with vitamin B6 deficiency. Urinary tryptophan matabolite data did

not differ between the vitamin-deficient women and the non-deficient women. The following biochemical criteria

were used to measure absolute B6 deficiency: 1) a raised HK/HA ratio; and 2)lowered Asp-AT activities. The

depression in women with vitamin B6 deficiency responded to administration of pyridoxine hydrochloride; depression

in the other women did not respond. Pyridoxine administration can correct 2 of the mechanisms whereby abnormal

depression occurs during oral contraceptive therapy: 1)by preventing accumulation of tryptophan metabolites which

inhibit tryptophan transport into the brain; and 2)by restoring normal activity of 5-hydroxytryptophan decarboxylase. It

has been suggested that pyridoxine supplements be given all women on oral contraceptives to prevent depression.

There are complications which might develop from universal pyridoxine administration. More research is needed into

the cause of depression in the other women in the study who did not exhibit vitamin B6 deficiency. (PubHealth.info

Document ID: CONT8T 586-06)



PubHealth.info NOTE: The author(s) of this article titled, "Effect of pyridoxine hydrochloride (vitamin B6) upon

depression associated with oral contraception.", is(are) Adams PW; Rose DP; Folkard J; Wynn V; Seed M;

Strong R. The source of this article is "Lancet1: 897-904. April 28, 1973.". This article was published in 1973 in

English language(s). (PubHealth.info® Document ID: CONT8T 586-06. All rights reserved with PubHealth.info) PIN:

35586




 

 

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