Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1973

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Effect of oral contraceptives on the cotton pellet-induced granuloma in rats.

AUTHORS

Razdan MK; Bhide NK

SOURCE

Journal of the Indian Medical Association 60: 3-4. January 1; 1973.

ABSTRACT

During a pharmacological screening study it was observed that rats fed on oral contraceptive preparation developed

smaller granuloma capsules than control animals. It was decided to study the effect of oral contraceptives on the

cotton pellet-induced granuloma in rats. Albino rats were anesthetized with ether and 4 sterile cotton pellets (10 mg

each) were inserted under aseptic conditions into the subcutaneous tissues of axillae and groins. Animals were

weighed and killed on the eighth day. Pellets with surrounding fibrous tissue capsules were dissected out, dried,

and weighed. Preparations containing 2.5 mg lynestrenol and .075 mg mestranol per tablet; .5 mg dl norgestrel and

.05 mg ethinylestradiol per tablet; medroxyprogesterone acetate and tablets containing lynestrenol 5 mg and

mestranol .15 mg were used. The drug was triturated with 1 ml groundnut oil and .4 ml polysorbate 80 (Tween 80)

and then emulsified in water. Emulsion of groundnut oil and polysorbate 80 in water was used for the control rats.

Drugs were given orally once a day for the first 5 days. Hydrocortisone was administered ip only once on the first day

(5 mg/rat) or as 2 injections (each 2.5 mg/rat) on the first and third days. Capsules of rats receiving larger doses of

preparations containing 2.5 mg lynestrenol and .075 mg mestranol per tablet; 2.5 mg norethisterone and .05 ethinyl

estradiol; .5 mg dl norgestrel and .05 mg ethinyl estradiol and medroxyprogesterone were smaller than those of the

control animals and the difference was statistically significant. The authors note that compared to the human

requirement, some doses of oral contraceptives used in this experiment are high, but that the rat is generally much

less sensitive to drugs than man. Because of the granuloma-suppressing action, these steroids are likely to delay

the fibrosis of the thrombus and thus further contribute to the clinical incidence of embolism. (PubHealth.info

Document ID: CONT8T 580-06)

PubHealth.info NOTE: The author(s) of this article titled, "Effect of oral contraceptives on the cotton pellet-induced

granuloma in rats.", is(are) Razdan MK; Bhide NK. The source of this article is "Journal of the Indian Medical

Association 60: 3-4. January 1; 1973.". This article was published in 1973 in English language(s). (PubHealth.info®

Document ID: CONT8T 580-06. All rights reserved with PubHealth.info) PIN: 35580

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