Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1973

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Effect of chronic administration of an oral contraceptive on the blood

pressure of rats.

AUTHORS

Fregly MJ

SOURCE

Toxicology and Applied Pharmacology 25: 560-568. 1973.

ABSTRACT

It was reported previously that the administration of Enovid to ovariectomized female rats for 8 months was

accompanied by an elevation of systolic blood pressure and cardiac enlargement. An experiment is described which

was conducted to confirm the earlier observation in intact female rats as well as to study the time course of

development of the contraceptive-induced elevation of blood pressure. In the first study described, 10 female rats

were given tap water and finely powdered Pruina Laboratory Chow ad libitum. Half of the group received Enovid mixed

into their ration at a concentration of 7.5 mg/kg of food throughout the 20-week experiment. An elevation of systolic

blood pressure and an increase in the ratios of both heart weight to body weight and renal weight to body weight

occurred. A second study, in which Enovid was administered at the same dose to 9 out of 21 rats, revealed

significant increases in systolic, diastolic, and mean blood pressures of treated female rats measured by direct

cannulation of the carotid artery. A third study rested the effect of the same dose of Enovid on the systolic pressure

of 5 out of 10 female rats receiving .15 M sodium chloride solution as their sole drinking fluid. The first significant

elevation of blood pressure in these rats occurred during Week 6 of drug treatment and continued for the remainder of

the 12-week experiment. The ratio of heart weight to body weight was also increased significantly in the treated

group. Thus, chronic administration of Enovid at the dosage used was accompanied by hypertension in rats. The

authors advise that since the rats received 2.8 times the daily dose of Enovid ingested by humans, the applicability

of the results of this experiment to humans cannot be stated with certainty until both lower doses and the separate

constituents are tested. (PubHealth.info Document ID: CONT8T 565-06)

PubHealth.info NOTE: The author(s) of this article titled, "Effect of chronic administration of an oral contraceptive on

the blood pressure of rats.", is(are) Fregly MJ. The source of this article is "Toxicology and Applied Pharmacology

25: 560-568. 1973.". This article was published in 1973 in English language(s). (PubHealth.info® Document ID:

CONT8T 565-06. All rights reserved with PubHealth.info) PIN: 35565

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