Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1970

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Menstrual dysfunction following use of oral contraceptives.

AUTHORS

Homesley HD; Goss DA

SOURCE

Obstetrics and Gynecology 35(5): 734-739. May 1970.

ABSTRACT

An evaluation of 13 patients with menstrual dysfunction following discontinuation of oral contraceptives is presented.

All had normal ovulatory cycles of 26-34 days before beginning oral contraceptive medication. The duration of

therapy was 3-42 months with 14 months the mean. Relationship between occurrence of menstrual dysfunction and

duration of therapy or type of agent administered was not noted. 9 were classified as amenorrheic (6 months or more

of secondary amenorrhea) and their condition lasted from 6 to 36 months. Cervical mucus from 6 demonstrated a 3

to 4+ fern phenomena, indicating significant endogenous estrogen production. Gynecologic endocrine status was

evaluated by basal body temperature, endometrial biopsy, and cervical mucus arborization. Total gonadotropins were

measured in those demonstrating poor or absent fern phenomenon. Adrenal and thyroid functions were measured by

17-ketosteroid and 17-hydroxysteroid excretion and PBI respectively. Patients were screened for pituitary tumors by

X-ray and visual examinations. Clomiphene (Clomid) was administered to 6 patients in 5 day courses of 50 or 100

mg per day. Of these 4 responded with ovulatory cycles. One became pregnant. 2 patients not responding to several

such courses, were given human menopausal gonadotropin (HMG Pregova) in doses of 140 I.U. a day until cervical

mucus demonstrated 4+ fern phenomenon. Human chorionic gonadotropin (HCG) was then given in a single dose of

5000 I.U. One responded to this treatment and became pregnant. 3 were not treated because they did not desire

conception or ovulation induction. The 4 patients who were amenorrheic for less than 6 months were considered

oligomenorrheic. 2 responded to clomiphene but the pattern of prolonged follicular phase has recurred in both.

Their menstrual dysfunction is thought to be due to delayed recovery from suppression of some hypothalamic-

pituitary mechanisms involved in normal gonadotropin regulation. Gonadtropin therapy is the only effective method of

ovulation induction in those patients who fail to respond to clomiphene. (PubHealth.info Document ID: CONT8T

4565-06)

PubHealth.info NOTE: The author(s) of this article titled, "Menstrual dysfunction following use of oral

contraceptives.", is(are) Homesley HD; Goss DA. The source of this article is "Obstetrics and Gynecology 35(5):

734-739. May 1970.". This article was published in 1970 in English language(s). (PubHealth.info® Document ID:

CONT8T 4565-06. All rights reserved with PubHealth.info) PIN: 39565

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