Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1974

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Rifampicin and oral contraception. (Letter to the editor)

AUTHORS

Bolt HM; Kappus H; Bolt M

SOURCE

Lancet 1(7869): 1280-1281. June 22, 1974.

ABSTRACT

Treatment with rifampicin has been shown to impair the effectiveness of oral contraceptive agents. Increased

incidence of spotting and breakthrough bleeding and cumulated occurrence of pregnancies have been reported in

tuberculous patients receiving rifampicin and oral contraceptives. Remmer et al. have found that rifampicin may

cause induction of drug-metabolizing enzymes in the endoplasmic reticulum of the human liver; and accordingly

these observations might possibly be explained by increased breakdown of the estrogenic component of

contraceptives in the liver. We determined the rate of aromatic hydroxylation of ethinly estradiol in vitro by

microsomal preparations from human livers with an NADPH (reduced form of nicotinadmide-adenine-dinucleotide-

phosphate) regenerating system. Our method is based on the replacement of tritium from the positions 2 and 4 of the

ethinyl estradiol molecule which is associated with hydroxylation at either of these positions. Aromatic hydroxylation

at C-2 and C-4 is the major pathway of ethinyl estradiol metabolism in man. With microsomes from a control group

of patients receiving no rifampicin, we found an aromatic hydroxylation rate of 237 + or - 104 pmo1/mg microsomal

protein per minute (M + or - standard deviation; n=12) at a substrate concentration of 20 mcm, whereas microsomes

from patients treated with rifampicin (600 mg) for 6 days hydroxylated ethinyl estradiol at a rate of 1108 + or - 487

pmo1/mg microsomal protein per minute (n=3). This more than fourfold increases in the velocity of breakdown of

ethinyl estradiol caused by rifampicin treatment may explain the reduced effectiveness of oral contraceptives in

patients receiving rifampicin. However, in such cases increasing the dose of estrogen prescribed might be expected

to enhance the safety of oral contraception. (PubHealth.info Document ID: CONT7T 3525-06)

PubHealth.info NOTE: The author(s) of this article titled, "Rifampicin and oral contraception. (Letter to the editor)",

is(are) Bolt HM; Kappus H; Bolt M. The source of this article is "Lancet 1(7869): 1280-1281. June 22, 1974.". This

article was published in 1974 in English language(s). (PubHealth.info® Document ID: CONT7T 3525-06. All rights

reserved with PubHealth.info) PIN: 33525

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