Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1977

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Liver tumors and oral contraceptives.

AUTHORS

KENT DR; NISSEN ED; NISSEN SE

SOURCE

International Journal of Gynaecology and Obstetrics 15(2):137-142. September-

October 1977.

ABSTRACT

The Liver Tumor Registry was established at the University of California Irvine Medical Center in early 1975 to

evaluate the possible association between oral contraception and liver tumors. This report is based on the 78 cases

for which analyses have been completed. Although these liver tumors may be benign, they are associated with

considerable morbidity and mortality. The principal danger lies in their extreme vascularity. Approximately 25% of

the cases reviewed by the Registry presented with hepatic rupture and hemoperitoneum, and 9 of the 78 patients

died. The data are based on cases with tumors found in women known to have taken oral contraceptives (OCs). The

etiologic factors considered were the age of the patient and the type and duration of OC therapy. More than 70% of

the women were between the ages of 20 and 35 when their tumors were 1st discovered. The remaining 28% were

over 35, and more than 1/2 of these were over 40. The mean duration of OC use for the patients studied was 58

months. Significantly, 85% of the patients had used OCs for more than 4 years, and more than 1/2 had used OCs for

longer than 5 years. Only 13.5% had less than 2 years exposure to OCs, suggesting that prolonged duration of OC

use appears to be an important factor in the development of liver tumors. Mestranol and ethinyl estradiol were the

only 2 estrogenic compounds found in the various OC products but 8 different progestogens were represented.

Virtually all combinations of OCs have been implicated. Although there may be an association between OC use and

malignant liver tumors, there is at present no clear evidence of a causal relationship. Focal nodular hyperplasia and

hepatic adenoma encompass 60 of the 78 Registry cases. The patient needs to undergo an exploratory laparotomy

and, in the majority of cases reviewed, treatment consisted of shelling out the tumor or partial hepatectomy.

(PubHealth.info Document ID: CONT7T 33-06)

PubHealth.info NOTE: The author(s) of this article titled, "Liver tumors and oral contraceptives.", is(are) KENT DR;

NISSEN ED; NISSEN SE. The source of this article is "International Journal of Gynaecology and Obstetrics

15(2):137-142. September-October 1977.". This article was published in 1977 in English language(s).

(PubHealth.info® Document ID: CONT7T 33-06. All rights reserved with PubHealth.info) PIN: 30033

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