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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.





YEAR: 1975




CATEGORY: Contraception (Birth Control) and Family Planning



TITLE



Pharmacological studies of a contraceptive drug Anordrin.



AUTHORS

Ku CP; Chu MK; Chiang HC; Chao SH; Pang TW; Tsou K


SOURCE

Scientia Sinica. 1975 Mar-Apr;18(2):262-70.



ABSTRACT

Promoted by the Great Proletarian Cultural Revolution and the struggle to criticize Lin Piao and Confucius under the

leadership of party organization at all levels, the 3-in-1 group formed by organizing the pharmaceutical factories,

scientific research institutes, and hospitals, armed with Mao Tsetung Thought, actively carried out a mass effort in

effective drug contraceptive research. As a result, a new oral contraceptive (OC), Anordrin, has been discovered. It

is an A-Nor-steroid with some estrogenic activity and possessing a significant antifertility activity in mice, rats,

rabbits, hamsters, and dogs. In rats, AF-53, administered repeatedly, led to sterility but did not alter mating behavior,

and the fertility of animals recovered soon after cessation of medication. In subminimal antifertility doses, it has no

teratogenic effect. Acute and chronic toxicity tests in animals showed that this drug did not cause any apparent

abnormality in the blood, liver and renal functions, or in the histological examination of organs. Experiments with

carbon-14 Anordrin showed that this drug could be absorbed rapidly but not completely in the gastrointestinal tract.

The peak blood level was usually attained at 9 hours postadministration. The drug excreted in the urine reached a

maximum in 10-12 hours. Higher radioactivity was found in bile and gastrointestinal tract and was also excreted in

large amounts in the feces. In clinical trials, it was administered only once postcoitally. The time for taking the drug

is not limited by the menstrual cycle and it is unnecessary to be taken successively. Thus, Anordrin is a

convenient, safe, and effective OC. (author's) (PubHealth.info Document ID: CONT7T 3046-06)



PubHealth.info NOTE: The author(s) of this article titled, "Pharmacological studies of a contraceptive drug Anordrin.",

is(are) Ku CP; Chu MK; Chiang HC; Chao SH; Pang TW; Tsou K. The source of this article is "Scientia Sinica.

1975 Mar-Apr;18(2):262-70.". This article was published in 1975 in English language(s). (PubHealth.info® Document

ID: CONT7T 3046-06. All rights reserved with PubHealth.info) PIN: 33046





 

 

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