Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1975

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Oral contraceptives: effects on plasma insulin response to glucose and on

the response to insulin and 2-deoxyglucose uptake by peripheral tissue

(38819)

AUTHORS

Lei KY; Yang MG; Oberleas D; Prasad AS

SOURCE

Proceedings of the Society for Experimental Biology and Medicine 149(2): 417-

ABSTRACT

Studies were conducted to determine whether peripheral tissue resistance to exogenous insulin exists in vivo and

whether an enhancement of plasma insulin response to oral glucose occurs in contraceptive-treated rats.

Experiments were designed to determine whether insulin resistance is due to a slower rate of glucose transport into

tissues. In female Sprague-Dawley rats, daily intake from the diet was about .1 mg of norethynodrel and 1.5 mcg of

mestranol per kg of body weight. In Experiment 1, oral glucose tolerance was tested by force-feeding glucose, 300

mg/100 gm of body weight. Blood samples for serum glucose determinations were obtained by heart puncture. 10

weeks of steroid treatment did not significantly modify the insulinogenic response to oral glucose. However, serum

glucose tolerance was reduced. In Experiment 2 the effect of the contraceptives on the insulin sensitivity of adipose

tissue and diaphragm was studied. Control and steroid-treated rats were injected iv with a tracer dose of glucose-U-

carbon-14 and .2 U of insulin per kg of body weight. Others were injected with the glucose-U-carbon-14 without

insulin. Animals were killed 15 minutes after injections. The diaphragm, parametrial fat, and blood were collected

for testing. Insulin stimulated the conversion of glucose into adipose tissue fatty acids and glycenide-glycerol and

into diaphragm glycogen but not adipose tissue glycogen. Serum levels of free fatty acids, glucose, and radioactive

materials were significantly lower in insulin-treated than in control rats. In steroid-treated animals, exogenous insulin

significantly reduced the conversion of blood glucose into fatty acids by the adipose tissue. In Experiment 3, the

effect of contraceptive steroids on the in vitro uptake of 2-deoxyglucose-1-carbon-14 (DOG) by peripheral tissue was

investigated. The method used is described. After 6 weeks of treatment DOG uptake by the hemidiaphragm and

adipose treatment was increased significantly as its concentration in the medium increased. However, the DOG

uptake was slightly higher in hemidiaphragms of control than of steroid-treated animals (p less than .1). Thus, any

decrease in glucose transport can account for only a small part of insulin resistance. (PubHealth.info Document ID:

CONT7T 3006-06)

PubHealth.info NOTE: The author(s) of this article titled, "Oral contraceptives: effects on plasma insulin response to

glucose and on the response to insulin and 2-deoxyglucose uptake by peripheral tissue (38819)", is(are) Lei KY;

Yang MG; Oberleas D; Prasad AS. The source of this article is "Proceedings of the Society for Experimental Biology

and Medicine 149(2): 417-421. 1975.". This article was published in 1975 in English language(s). (PubHealth.info®

Document ID: CONT7T 3006-06. All rights reserved with PubHealth.info) PIN: 33006

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