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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.





YEAR: 1977




CATEGORY: Contraception (Birth Control) and Family Planning



TITLE



Liver neoplasia and oral contraceptives.



AUTHORS

NISSEN ED; NISSEN SE; KENT DR


SOURCE

Paper presented at the Program for Applied Research on Fertility Regulation

(PARFR) Workshop on Risks, Benefits, and Controversies in Fertility Control,

Arlington, Virginia, March 13-16, 1977. 21 p



ABSTRACT

78 cases of benign hepatic neoplasia in young women exposed to oral contraceptives (OCs) are analyzed in an

attempt to assess the clinical and epidemiologic features of the syndrome. 78% of the patients were exposed to

mestranol-containing products for 80% of the total pill-months. Only 17% took ethinyl estradiol for 11% of the total pill-

months. Of 8 different progestogens available, 57% took norethindrone for 49% of pill-months. More than half the

patients took OCs for longer than 5 years. 85% were exposed for more than 4 years. The semantics involved in

describing this disease is a significant problem in reconciliation of case reports. It is believed, however, that nearly

all benign liver tumors in OC users are closely related to the prototypic lesion, the hepatic adenoma. The vascular

changes associated with this tumor represent the primary danger. Early diagnosis is difficult because of a lack of

good screening techniques. This problem is compounded by the symptom free condition of most patients until the

disease reaches advanced stages. The mechanism of pathogenesis is unknown. Various known effects of OC

steroids may play a role including cholestasis, hypercoagulation, vascualr wall thickening, and induction of the

hepatic intracellular enzyme system. A genetic deficiency in some women may prevent normal metabolism of

mestranol. (PubHealth.info Document ID: CONT7T 30-06)



PubHealth.info NOTE: The author(s) of this article titled, "Liver neoplasia and oral contraceptives.", is(are) NISSEN

ED; NISSEN SE; KENT DR. The source of this article is "Paper presented at the Program for Applied Research on

Fertility Regulation (PARFR) Workshop on Risks, Benefits, and Controversies in Fertility Control, Arlington, Virginia,

March 13-16, 1977. 21 p". This article was published in 1977 in English language(s). (PubHealth.info® Document

ID: CONT7T 30-06. All rights reserved with PubHealth.info) PIN: 30030





 

 

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