Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1977

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Liver lesions and oral contraceptive steroids.

AUTHORS

BARROWS GH; CHRISTOPHERSON WM; DRILL VA

SOURCE

Journal of Toxicology and Environmental Health 3(1-2):219-230. September 1977.

ABSTRACT

Swiss-Webster random-bred mice were administered norethynodrel (1.25 mg/kg/day) and a norethynodrel-mestranol

combination (.05 mg/kg/day) from 50 to 80 weeks. Liver sections of 1190 CF-LP mice given low, intermediate, and

high doses of norethynodrel, mestranol, and a combination of these drugs, were obtained from the Searle Company.

Histologic examination of the livers was performed without knowledge of the treatment or control status of the animal.

No increased incidence of hepatocellular tumors was found beyond the variation expected by chance. The overall

tumor incidence in treated and untreated groups was identical. No significant increase in tumor size was observed

in the treated mice. Liver weights progressively increased in several of the treated groups. In both treated and

untreated animals hepatocellular neoplasia was usually accompanied by intracytoplasmic inclusions similar to

those observed in human liver tumors. Vascular lesions were observed in some of the animals receiving large doses

of contraceptive steroids. While these may be the result of local toxicity, their similarity to lesions observed in

benign liver tumors warrants further study. No evidence was found to suggest that contraceptive steroids act as

initiators of liver neoplasia.(AUTHORS', MODIFIED) (PubHealth.info Document ID: CONT7T 29-06)

PubHealth.info NOTE: The author(s) of this article titled, "Liver lesions and oral contraceptive steroids.", is(are)

BARROWS GH; CHRISTOPHERSON WM; DRILL VA. The source of this article is "Journal of Toxicology and

Environmental Health 3(1-2):219-230. September 1977.". This article was published in 1977 in English language(s).

(PubHealth.info® Document ID: CONT7T 29-06. All rights reserved with PubHealth.info) PIN: 30029

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