Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1983

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Oral contraception with a nonalkylated estrogen component. Effects on lipid

metabolism.

AUTHORS

Samsioe G; Skryten A; Silfverstolpe G

SOURCE

Gynecologic and Obstetric Investigation. 1983 May;15(5):275-82.

ABSTRACT

Studies in postmenopausal women have demonstrated that nonalkylated 'natural' estrogens have less adverse

effects on lipoprotein metabolism than 17-C-alkylated estrogens (ethinyl estradiol and mestranol) which are the

estrogen components of all present commercially available oral contraceptives (OCs). The study objective was to

evaluate if this difference was valid also in young women on OCs. A comparison was made of the effects on serum

and lipoprotein lipids of 2 preparations with the same progestogen but with nonalkylated 'natural' or alkylated

'synthetic' estrogen as the other component. 8 women (Goteborg, Sweden) who had not used OCs before participated

in the study. No patient had any disease known to influence lipid metabolism or had any medication. The 2

preparations evaluated were Netasyn (50 mcg ethinyl estradiol plus 3 mg norethindrone acetate) and Netagen (4 mg

17 beta-estradiol plus 2 mg estriol plus 3 mg norethindrone acetate). No significant change in blood pressure or

body weight was recorded on any of the preparations. Netasyn increased the serum triglycerides and the triglyceride

content of all lipoprotein fractions. There was also an increase in LDL-CH and a decrease in HDL-CH on this

preparation. Netagen like Netasyn increased LDL-TG, but it also reduced the phospholipid content of HDL and the

cholesterol component of VLDL. No significant changes were induced by any of the preparations in routine liver

function tests and pretreatment and treatment levels were within the normal range for all patients. Netasyn caused a

shift in the fatty acids in 1 position of serum lecithin. There was an increase in palmitric and a concomitant

decrease in stearic acid. The increase in serum triglyceride induced by Netasyn was different from the effect exerted

by Netagen. As regards the relative fatty acid composition of serum lecithin, the increase in palmitic and the

decrease in stearic acids was significantly different from the effects induced by Netasyn. (PubHealth.info Document

ID: CONT5T 2064-06)

PubHealth.info NOTE: The author(s) of this article titled, "Oral contraception with a nonalkylated estrogen

component. Effects on lipid metabolism.", is(are) Samsioe G; Skryten A; Silfverstolpe G. The source of this article

is "Gynecologic and Obstetric Investigation. 1983 May;15(5):275-82.". This article was published in 1983 in English

language(s). (PubHealth.info® Document ID: CONT5T 2064-06. All rights reserved with PubHealth.info) PIN: 22064

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