Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1983

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

New roads to contraception.

AUTHORS

Jirasek JE

SOURCE

CESKOSLOVENSKA GYNEKOLOGIE. 1983 Dec;48(10):764-8.

ABSTRACT

Brief state-of-the-art reviews on contraceptive vaccination, male contraceptives, and synthesis of antiprogestagenic

steroids for contraception are presented. Most studies on contraceptive vaccination are devoted to the synthesis and

application of anti-human chronic gonadotropin (anti-HCG) vaccines. As a result, antibodies were developed that

specifically react with HCG in vitro and neutralize its biological activity in vivo. Clinical studies are in progress to

examine the possible side effects of the vaccines. In a clinical study of 300 volunteers, several steroid formulations

were examined to determine their effectiveness as male contraceptives. Preliminary tests screened out the

combination of testosterone enanthate and methoxyprogesterone acetate as the most effective of the preparations

studied. The preparation caused azoospermia and oligospermia in 70% and 30% of the cases under study,

respectively. These data indicate that exogenous steroids can inhibit spermatogenesis and cause infertility in men.

In 1982, a new steroid, RU-486, was synthesized in France, with a strong affinity toward progesterone receptors and

no gestagenic or estrogenic physiological effects. Researchers have not revealed the chemical structure of the

preparation, but indicate that it belongs to the group of substituted 19-nor-steroids. Clinical tests show that the

contraceptive action of RU-486 is caused by the blocking of progesterone receptors. It is considered a promising

candidate for the development of a "once a month" pill. (PubHealth.info Document ID: CONT5T 2034-06)

PubHealth.info NOTE: The author(s) of this article titled, "New roads to contraception.", is(are) Jirasek JE. The

source of this article is "CESKOSLOVENSKA GYNEKOLOGIE. 1983 Dec;48(10):764-8.". This article was published

in 1983 in Czech language(s). (PubHealth.info® Document ID: CONT5T 2034-06. All rights reserved with

PubHealth.info) PIN: 22034

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