Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1983

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

New contraceptives for men. What are the prospects? [editorial]

AUTHORS

Prasad MR; Diczfalusy E

SOURCE

International Journal of Andrology. 1983 Aug;6(4):305-9.

ABSTRACT

This article reviews the seach for an effective, safe, and reversible method for the regulation of male fertility. Aside

from vasectomy and gossypol (in China), no approach has reached the stage of large clinical trials. The World

Health Organization (WHO) and the National Institutes of Child Health and Human Development (NICHD) are involved

in a joint effort to prepare highly purified gossypol acetic acid to serve as an internationally available reference

standard and have established a program for the synthesis and screening of analogues of gossypol and related

compounds with a more favorable therapeutic profile. WHO and NICHD are also collaborating in a development

program for synthesizing and screening longacting androgens with a longer duration of action than preparations

currently available. It is unlikely that any new combinations of gestagens and androgens will be available before the

end of the next decade, given the need for toxicological, mutagenic, and teratogenic evaluation. Successful use of

luteinizing release hormone (LRH) agonists for male fertility control depends on the availability of a longacting

delivery system to obviate the necessity of daily administration. In this case, a longacting androgen would have to be

administered concomitantly to counter the decreased libido caused by the reduction of levels of endogenous

androgens. Continued research is needed to elucidate the role of follicle-stimulating hormone (FSH) in the

regulation of spermatogenesis, as is assessment of the longterm safety of active immunization with FSH

preparations. Major progress has been made int he extraction, purification, and characterization of inhibin, as well as

the development of in vivo and in vitro models for the evaluation of its effects and of radioimmunoassay procedures

for its measurement. When the amino acid sequence of inhibin is known, it may be possible to prepare longer acting

and more potent synthetic analogues. The possibility of developing FSH antagonists by chemical deglycosylation

to selectively suppress spermatogenesis has also attracted interest. There has been no progress with regard to

selective interference with sperm maturation in the epididymis. The success of an immunological approach to male

fertility control depends on the identification, isolation, and purification of an epididymal constituent associated with

sperm maturation in the epididymis. (PubHealth.info Document ID: CONT5T 2032-06)

PubHealth.info NOTE: The author(s) of this article titled, "New contraceptives for men. What are the prospects?

[editorial]", is(are) Prasad MR; Diczfalusy E. The source of this article is "International Journal of Andrology. 1983

Aug;6(4):305-9.". This article was published in 1983 in English language(s). (PubHealth.info® Document ID:

CONT5T 2032-06. All rights reserved with PubHealth.info) PIN: 22032

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