Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1983

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

New approaches to female contraception: LHRH.

AUTHORS

Nillius SJ

SOURCE

In: Benagiano G, Diczfalusy E, ed. Endocrine mechanisms in fertility regulation.

New York, Raven, 1983. :163-93. Comprehensive Endocrinology

ABSTRACT

Recent clinical research on the role of the luteinizing hormone-releasing hormone (LHRH) and its analogs in the

control of fertility is reviewed. The amino acids histidine and tryptophan in positions 2 and 3 appear to play a

functional role in the biological activity of LHRH. Potent stimulatory analogs, with enhanced biological activity

presumably due to their resistance to inactivation and to increased pituitary binding, have been developed. Several

antagonistic analogs have been developed as well, but are not powerful enough to be useful clinically. In male and

female animals, successful immunization aganst LHRH produces complete inhibition of reproductive function. The

antagonistic analogs of LHRH can block ovulation and prevent pregnancy in rats, but inhibitory effects have not been

as marked in primates. The superactive agonistic analogs exert paradoxical antifertility effects, inducing

desensitization of the processes responsible for pituitary gonadotropic and gonadal hormone secretion. 2 new

approaches to female contraception based on LHRH and its analogs are currently under clinical investigation. The

1st involves induction of luteolysis with LHRH and its agonist analogs, and the 2nd centers aroung daily intranasal

administration of a potent stimulatory LHRH analog. LHRH agonist induction of luteolysis with premature onset of

menstruation has been documented in several studies, although the timing of agonist administration seems to be

critical for its effectiveness. The prospects for clinical contraceptive application of LHRH agonists as luteolytic

agents are reduced by the fact that both exogenous and endogenous human chorionic gonadotropins can overcome

the luteolytic effect. Chronic LHRH agonist treatment, on the other hand, has documented contraceptive

effectiveness and short term safety and constitutes a promising new approach to female contraception.

(PubHealth.info Document ID: CONT5T 2029-06)

PubHealth.info NOTE: The author(s) of this article titled, "New approaches to female contraception: LHRH.", is(are)

Nillius SJ. The source of this article is "In: Benagiano G, Diczfalusy E, ed. Endocrine mechanisms in fertility

regulation. New York, Raven, 1983. :163-93. Comprehensive Endocrinology". This article was published in 1983 in

English language(s). (PubHealth.info® Document ID: CONT5T 2029-06. All rights reserved with PubHealth.info) PIN:

22029

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