Contraception (Birth Control) and Family Planning PubHealthInfo

[PubHealth.info Homepage] [Category Homepage] [Disclaimer/Copyrights] [Feedback]

Thank you for your kind visit to PubHealth.info®, an information portal created in technical collaboration with PakMed Biomedical Solutions * * * PubHealth.info® presents hundreds of thousands of informative Web pages on a variety of public health issues / issues * * * An ultimate source of information for teachers, students and research workers who need to find information on various public health issues, like population planning, contraception, HIV AIDS, STDs, maternal and child health, communicable and non-communicable disease, etc. * * * PubHealth.info® regularly updates the repository of these hundreds of thousands of informative Web pages * * * PubHealth.info® is one of the world's largest repositories and information portals with online Web pages on public health issues particularly those pertaining to developing countries!

PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1983

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Myocardial infarction, oral contraception, cigarette smoking, and coronary

artery spasm in young women.

AUTHORS

Jugdutt BI; Stevens GF; Zacks DJ; Lee SJ; Taylor RF

SOURCE

American Heart Journal. 1983 Oct;106(4 Pt 1):757-61.

ABSTRACT

Previous research has suggested that the combination of cigarette smoking and oral contraceptive (OC) use provides

a strong stimulus for platelet aggregation, coronary spasm, and thrombosis. This paper presents the cases of 2

patients with myocardial infarction (MI) in whom smoking and OC use appeared to be contributory factors. The cases

were part of a series of 65 women with atypical chest pains and normal coronary arteriograms who were followed in

1977-79. The 1st case, a previously healthy 28-year old, had been taking Ortho-novum 1-50 for 4 years and had

smoked 40 cigarettes/day for 12 years prior to MI. No other risk factors for premature atherosclerosis were present.

The electrocardiogram (ECG) revealed transmural inferior and anteroapial MI. Left ventricular angiography showed an

anteroapial aneurysm with a large thrombus; the ejection fraction was 39%. Ergovine testing was positive.

Cornonary arteriography showed normal coronary arteries except for a catheter-induced spasm of the proximal right

coronary artery and segmental narrowing of the distal two thirds of the left anterior descending artery. OC use was

discontinued and oral anticoagulants were administered. 2 years later the thrombus was not detectable. The 2nd

case, 39 years old, took OCs for 9 months 15 years prior to admission and smoked 50 cigarettes/day for 20 years.

ECG revealed an old inferior MI. Angiocardiography showed left ventricular enlargement and an ejection fraction of

51%. The coronary arteriogram revealed noncritical fixed lesions (40%) of the left circumflex, diagonal branch, and

right coronary arteries. Only a 25% caliber reduction was induced by ergovine. It is hypothesized that cigarette

smoking precipitated coronary artery spasm in the 1st case through the nicotine-induced release of norepinephrine

and diminished prostacyclin/thromboxane A2 ratio. The combination of cigarette smoking and estrogen may have

created a cycle of platelet aggregation, vasoconstriction, and thrombosis, leading to MI. Although further studies are

needed to confirm this hypothesis, the reports suggest that provocative testing for coronary spasm should be

considered in young women with MI or angina and normal or near normal arteries. (PubHealth.info Document ID:

CONT5T 2006-06)

PubHealth.info NOTE: The author(s) of this article titled, "Myocardial infarction, oral contraception, cigarette smoking,

and coronary artery spasm in young women.", is(are) Jugdutt BI; Stevens GF; Zacks DJ; Lee SJ; Taylor RF. The

source of this article is "American Heart Journal. 1983 Oct;106(4 Pt 1):757-61.". This article was published in 1983 in

English language(s). (PubHealth.info® Document ID: CONT5T 2006-06. All rights reserved with PubHealth.info) PIN:

22006

This page is optimized to be viewed by Java script enabled Microsoft® Internet Explorer 6 or later version, at screen resolution of 800 by 600 pixels.