Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1991

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Immunocontraception -- a family planning possibility of the future.

[Immunkontraception -- framtida mojlighet till familjeplanering.]

AUTHORS

Nilsson O

SOURCE

LAKARTIDNINGEN. 1991 Nov 13;88(46):3885-6, 3891.

ABSTRACT

The key to immunological contraception is production of antibodies that inactivate or block conception. Research on

vaccines aims at providing protection for 1-2 years and lifelong protection could replace sterilization. Ethical

considerations prompt the avoidance of interruption of pregnancy but even antibodies that could interrupt the

implantation process are acceptable in view of present population pressures. Research strategies involve finding a

male immunogen such as a sperm component, and after animal tests, evaluate it in 3-phase human volunteer

experiments lasting about 10 years. Possible targets are antibodies against gonadotropin releasing hormone (GnRH)

resulting in missed ovulation, interruption of pregnancy, and reduced spermatogenesis, however, changes in sex

glands rule it out. Follicle stimulating hormone vaccine in animals deleteriously affected testosterone levels, also

disqualifying it. Among sperm antibodies the enzyme lactate dehydrogenase-C4 is specific for acrosomes; in guinea

pigs and antigen PH-20 necessary for the attachment of sperm to zona pellucida was effective. Targeting egg cells

by antibodies avoids ethical problems as no fertilization takes place, and finding the proper antigen for a vaccine is

viable. Implantation involving blastocytes and trophoblast cells is another mechanism. Developing antibodies

against the secretion product of trophoblast, human chorionic gonadotropin (hCG) has been conducted by the World

Health Organization. An Indian method entered phase-2 trials, and after 2-4 immunizations it gave results without

serious side effects. Recently there has been renewed interest in such research in addition to the WHO and several

US organizations because of the relentless population growth. (PubHealth.info Document ID: CONT3T 2057-06)

PubHealth.info NOTE: The author(s) of this article titled, "Immunocontraception -- a family planning possibility of the

future. [Immunkontraception -- framtida mojlighet till familjeplanering.]", is(are) Nilsson O. The source of this article

is "LAKARTIDNINGEN. 1991 Nov 13;88(46):3885-6, 3891.". This article was published in 1991 in Swedish

language(s). (PubHealth.info® Document ID: CONT3T 2057-06. All rights reserved with PubHealth.info) PIN: 12057

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