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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.





YEAR: 1991




CATEGORY: Contraception (Birth Control) and Family Planning



TITLE



Hormonal content of combined oral contraceptives in relation to the reduced

risk of endometrial carcinoma.



AUTHORS

Rosenblatt KA; Thomas DB


SOURCE

INTERNATIONAL JOURNAL OF CANCER. 1991 Dec 2;49(6):870-4.



ABSTRACT

A retrospective case-control study of endometrial cancer and use of combined oral contraceptives by formulation,

including 220 cases and 1537 age- and hospital-matched controls from 9 centers in 7 countries, conducted by WHO

found reduced risk with high-progestin dose pills. Women born after 1925-1930, with histologically diagnosed

endometrial carcinoma, were matched with up to 8 controls taken from patients admitted with 24 hours of diagnosis,

who had no contraindication to taking orals. The histologic type of endometrial carcinoma in cases were

adenocarcinomas 88.2%, adenosquamous 7.3%, clear-cell 1.8%, undifferentiated 1.8%, and squamous 0.9%. Oral

contraceptives were classified by progestogen activity according to the subnuclear vacuolization scheme of Dickey,

and pills were considered low-dose estrogen is they contained <50 mcg ethinyl estradiol for <100 mestranol. Odds

ratios, calculated by conditional logistic regression, were 0.00 (95% confidence limits 0.00-1.08) for high dose

progestin/low dose estrogen pills, and 1.10 (0.13-9.06) for low progestin/high estrogen pills. Odds ratios for high

estrogen/high progestin, and low estrogen/low progestin were in between, 0.15 and 0.59. The odds ratio for all high-

dose progestin pills combined was 0.21, and lasted over 10 years, even if a woman had taken them for <2 years.

Protection against endometrial cancer for those who took low-dose progestin pills was not apparent until >2 years of

use, and lasted <10 years. 2 of 3 previous studies on oral contraceptives by formulation and endometrial cancer

obtained similar results. (PubHealth.info Document ID: CONT3T 2047-06)



PubHealth.info NOTE: The author(s) of this article titled, "Hormonal content of combined oral contraceptives in

relation to the reduced risk of endometrial carcinoma.", is(are) Rosenblatt KA; Thomas DB. The source of this

article is "INTERNATIONAL JOURNAL OF CANCER. 1991 Dec 2;49(6):870-4.". This article was published in 1991 in

English language(s). (PubHealth.info® Document ID: CONT3T 2047-06. All rights reserved with PubHealth.info) PIN:

12047





 

 

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