Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1991

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Proliferation and DNA ploidy in malignant breast tumors in relation to early

oral contraceptive use and early abortions.

AUTHORS

Olsson H; Ranstam J; Baldetorp B; Ewers SB; Ferno M; Killander D;

SOURCE

CANCER. 1991 Mar 1;67(5):1285-90.

ABSTRACT

In 175 premenopausal breast cancer patients, a history of oral contraceptive (OC) use prior to age 20 was

significantly associated with high tumor cell proliferative activity, as indicated by a higher S-phase fraction (SPF),

and a higher fraction of DNA aneuploid tumors, compared with later or never users (p=0.05 and p=0.01, respectively).

The higher SPF among early OC users was apparent in patients with aneuploid tumors but not in patients with

euploid tumors. Abortions (both induced and spontaneous) before the 1st fullterm pregnancy also were associated

with a higher SPF compared with other young patients with breast cancer (p=0.03). Adjusting for parity and abortions

or OC use, respectively, an early OC use was associated with a 43% higher SPF and early abortions were associated

with 49% higher SPF. Younger patients had a higher SPF and a higher frequency of aneuploid tumors, but this was

found to be because the users of OCs had a lower median age at diagnosis. Among never users, no significant age

relationship was seen for SPF or the frequency of aneuploidy. For the DNA analyses, there is a selection of patients

with breast cancer with larger tumors, and therefore, the conclusions drawn in this article may not be generalizable to

patients with smaller primary tumors; e.g. cases diagnoses at breast cancer screening. The higher tumor

proliferative activity and frequency of aneuploidy in early OC users are in line with previously reported findings of

worse prognostic indicators and a worse survival rate in early users of OCs as compared to other young women with

breast cancer. (author's) (PubHealth.info Document ID: CONT3T 2015-06)

PubHealth.info NOTE: The author(s) of this article titled, "Proliferation and DNA ploidy in malignant breast tumors in

relation to early oral contraceptive use and early abortions.", is(are) Olsson H; Ranstam J; Baldetorp B; Ewers SB;

Ferno M; Killander D; Sigurdsson H. The source of this article is "CANCER. 1991 Mar 1;67(5):1285-90.". This article

was published in 1991 in English language(s). (PubHealth.info® Document ID: CONT3T 2015-06. All rights reserved

with PubHealth.info) PIN: 12015

This article is peer-reviewed.

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