Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1991

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Oral contraceptives increase insulin-like growth factor binding protein-1

concentration in women with polycystic ovarian disease.

AUTHORS

Suikkari AM; Seppala M; Tiitinen A; Laatikainen T; Stenman UH

SOURCE

FERTILITY AND STERILITY. 1991 May;55(5):895-9.

ABSTRACT

Insulin-like growth factor-I (IGF-I) stimulates ovarian androgen production. Insulin-like growth factor binding protein-1

(IGFBP-1) inhibits IGF actions in vitro. The objective of this study was to investigate the effect of oral contraceptives

(OCs), administered for 3 months, on serum gonadotropin, androgen, IGF-I, and IGFBP-1 concentrations, and glucose

tolerance in 7 women with polycystic ovarian disease (PCOD) and in 5 healthy subjects. An oral glucose tolerance

test (OGTT) was performed before and after treatment with OCs. After treatment, serum luteinizing hormone,

androstenedione, and free testosterone levels decreased, and sex hormone-binding globulin concentrations

increased in the women with PCOD as well as in the controls. The cumulative response of serum insulin to OGTT

was larger in women with PCOD than in the controls, both before and after treatment. Serum IGF-I concentration,

which was unchanged during OGTT, decreased from a basal level of 326 +or- 70 mcg/L to 199 +or- 28 mcg/L after

OC treatment in those women with PCOD, whereas no change was found in the controls (from 235 +or- 11 mcg/L to

22 +or- 11 mcg/L). Treatment with OCs caused an increase in the mean basal IGFBP-1 concentrations from 24 +or-

7 mcg/L to 73 +or- 14 mcg/L in the women with PCOD. This increase was constant during OGTT. Among the

control subjects, treatment with OCs did not result in any significant change in IGFBP-1 concentrations (from 44 +or-

mcg/L to 61 +or- 9 mcg/L). The combination of decreased total IGF-1 concentration and increased IGFBP-1

concentration induced by OCs may decrease ovarian androgen production in PCOD. (PubHealth.info Document ID:

CONT3T 2007-06)

PubHealth.info NOTE: The author(s) of this article titled, "Oral contraceptives increase insulin-like growth factor

binding protein-1 concentration in women with polycystic ovarian disease.", is(are) Suikkari AM; Seppala M;

Tiitinen A; Laatikainen T; Stenman UH. The source of this article is "FERTILITY AND STERILITY. 1991

May;55(5):895-9.". This article was published in 1991 in English language(s). (PubHealth.info® Document ID:

CONT3T 2007-06. All rights reserved with PubHealth.info) PIN: 12007

This article is peer-reviewed.

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