Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1992

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

The new era in oral contraception: pills containing gestodene, norgestimate,

and desogestrel.

AUTHORS

London RS

SOURCE

OBSTETRICAL AND GYNECOLOGICAL SURVEY. 1992 Nov;47(11):777-82.

ABSTRACT

The latest advance in the 30-year evolution of oral contraceptives (OCs) is the development of 3 new progestogens:

desogestrel, norgestimate, and gestodene. These 3 new agents are derivatives of levonorgestrel, a gonane

hormone, and have been used to develop pills that provide effective pregnancy prevention at lower doses than OCs

using the older steroids. Desogestrel is a prohormone that must first be metabolized into its biologically active form.

Norgestimate is already active, but it will be metabolized in part to levonorgestrel. Gestodene is biologically active

in its native form. Among the improvements in metabolic parameters seen with this new generation of progestogens

are a lack of impact on blood pressure, a balanced effect on coagulation, and a reduced impact on carbohydrate

metabolism compared with earlier, higher-dose formulations. The new pills also seem to produce no negative

effects on lipid an lipoprotein biosynthesis, and perhaps even improve the ratio of low-density lipoprotein to high-

density lipoprotein. Cycle control with all 3 progestogens is improved, with much lower incidence of intermenstrual

bleeding (IMB). Efficacy is as good as with other OCs. Another benefit of the new low-dose progestogens, however,

is the low incidence of minor side effects observed in women using these contraceptives. Low incidences of weight

gain, headache, and nausea were reported, and the dropout rate because of side effects was low in both

international and US trials. Serious side effects are rarely seen with pills containing the new progestogens. The

development of gestodene, desogestrel, and norgestimate will provide expanded OC choices for women, with the

promise of efficacy equal to and safety and cycle control improved over previous higher-dose OCs. (author's)

(PubHealth.info Document ID: CONT3T 1580-06)

PubHealth.info NOTE: The author(s) of this article titled, "The new era in oral contraception: pills containing

gestodene, norgestimate, and desogestrel.", is(are) London RS. The source of this article is "OBSTETRICAL AND

GYNECOLOGICAL SURVEY. 1992 Nov;47(11):777-82.". This article was published in 1992 in English language(s).

(PubHealth.info® Document ID: CONT3T 1580-06. All rights reserved with PubHealth.info) PIN: 11580

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