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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.





YEAR: 1992




CATEGORY: Contraception (Birth Control) and Family Planning



TITLE



New concepts in oral contraceptive pill use.



AUTHORS

Zacur HA; Stewart D


SOURCE

CURRENT OPINION IN OBSTETRICS AND GYNECOLOGY. 1992 Jun;4(3):365-71.



ABSTRACT

Over the 30 years since combined oral contraceptives (OCs) first emerged, scientists have learned that reducing the

estrogen component by 80% and the progestogen component by 90% provides adequate contraception and reduces

adverse side effects. Their better understanding of the mechanisms of the metabolism of estrogens and

progestogens contained in these OCs has allowed them to develop new progestogens, all modifications of

levonorgestrel. These new progestogens include desogestrel, gestodene, and norgestimate which further reduce the

likelihood of androgenic side effects and adverse changes of blood lipids, coagulation, and carbohydrate

metabolism. They were first introduced in Europe and are expected to be approved by the US Food and Drug

Administration soon. The improved understanding of the metabolic mechanisms has also allowed scientists to

learn about the role of the cytochrome P-450 hydroxylating enzyme system in steroid metabolism and about

interactions of OCs with other drugs. This hepatic system 2-hydroxylates ethinyl estradiol and eliminates it more

rapidly from the body; so inhibiting 2-hydroxylase activity would make ethinyl estradiol more powerful, while

stimulating it would reduce ethinyl estradiol's potency. This discovery alerts physicians to be cautious when

prescribing other medications, while a woman is taking an OC, that could induce or inhibit this enzyme system, e.g.,

rifampicin (an inducer) and cimetidine (an inhibitor). Scientific documentation for a justification of the pill-free

interval does not exist. Disadvantages of the pill-free interval include estrogen withdrawal symptoms, e.g., migraine

headaches and the risk of reduced contraceptive efficacy. (PubHealth.info Document ID: CONT3T 1574-06)



PubHealth.info NOTE: The author(s) of this article titled, "New concepts in oral contraceptive pill use.", is(are) Zacur

HA; Stewart D. The source of this article is "CURRENT OPINION IN OBSTETRICS AND GYNECOLOGY. 1992

Jun;4(3):365-71.". This article was published in 1992 in English language(s). (PubHealth.info® Document ID:

CONT3T 1574-06. All rights reserved with PubHealth.info) PIN: 11574





 

 

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