Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1997

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Development of male contraceptive vaccine -- a perspective.

AUTHORS

Moudgal NR; Jeyakumar M; Krishnamurthy HN; Sridhar S; Krishnamurthy H;

SOURCE

HUMAN REPRODUCTION UPDATE. 1997 Jul-Aug;3(4):335-46.

ABSTRACT

Recent advances in basic understanding of gonadotrophin action have facilitated the development of candidates for

a male contraceptive vaccine. This article reviews the current status of the following such candidates: luteinizing

hormone-releasing hormone (LHRH), follicle-stimulating hormone (FSH), and LH and FSH receptor proteins. Studies

based primarily on non-human primates indicate the vaccines are well tolerated, with no known toxic symptoms or

immediate health hazards. The addition of acceptable immune stimulators to the adjuvant cocktail and the

development of better immunization schedules or immunogen delivery systems may enable increases in antibody

titers and prolongation of the immune response. The task at this point is careful evaluation of the bioefficacy of

antibodies raised to recombinant ovine FSH-beta or FSH receptor protein fragments in both human and non-human

primates. The FSH/FSH receptor has the advantage of not requiring an exogenous testosterone supplement to

maintain accessory gland function or libido. The LHRH/LH-based vaccine results in azoospermia, while the FSH

vaccine causes the production of low numbers of poor quality spermatozoa incapable of impregnating cycling

females. The most likely regimen includes the administration of two injections of the immunogen 20 days apart

followed by boosters of either LHRH or FSH once every 3-6 months. (PubHealth.info Document ID: CONT2T 553-06)

PubHealth.info NOTE: The author(s) of this article titled, "Development of male contraceptive vaccine -- a

perspective.", is(are) Moudgal NR; Jeyakumar M; Krishnamurthy HN; Sridhar S; Krishnamurthy H; Martin F. The

source of this article is "HUMAN REPRODUCTION UPDATE. 1997 Jul-Aug;3(4):335-46.". This article was published

in 1997 in English language(s). (PubHealth.info® Document ID: CONT2T 553-06. All rights reserved with

PubHealth.info) PIN: 5553

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