Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1993

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Pulsatile luteinizing hormone secretion during the first and the fourth

cycle on two different oral contraceptives containing gestodene.

AUTHORS

Hemrika DJ; Slaats EH; Kennedy JC; de Vries Robles-Korsen TJ; Schoemaker J

SOURCE

ACTA ENDOCRINOLOGICA. 1993 Sep;129(3):229-36.

ABSTRACT

Oral contraceptives (OCs) inhibit ovarian follicular growth by suppressing the release of gonadotropins from the

pituitary. The authors studied basal and gonadotropin-releasing hormone-stimulated gonadotropin release, as well

as pulsatile luteinizing hormone (LH) secretion, in 10 healthy volunteers who had not used OCs before. Subjects

received either a monophasic preparation containing 30 mcg of ethinyl estradiol and 75 mcg of gestodene (group 1)

or a triphasic formulation containing 30-40 mcg of ethinyl estradiol and 50, 70, and 100 mcg of gestodene (group 2).

Blood sampling at 10-minute intervals during 6-hour periods was performed on days 1, 8, 15, and 21 of both the first

and fourth pill cycle. 13 healthy volunteers with regulatory ovulatory cycles served as normal controls. Both LH and

follicle-stimulating hormone (FSH) were measured by a sensitive immunoradiometric assay. Pulsatile LH secretion

was observed in all OC users. Mean serum LH and FSH levels, number of pulses/6 hours and the amplitude of LH

pulses on day 1 in both the first and fourth pill cycle did not differ from early follicular phase controls in both groups.

The FSH levels were suppressed rapidly in both groups, even in first cycles, while LH serum levels progressively

declined in all cycles studied. In both groups, amplitudes of LH pulses decreased from day 8 onwards, with a

substantial number of low-amplitude pulses (< 0.75 U/l) interspersed between large-amplitude pulses. On day 1 of

the fourth pill cycle, a significant number of pulses were of low amplitude. These results confirm our earlier findings

that pulsatile secretion of gonadotropins is maintained during OC use but is profoundly modified by steroid feedback.

There seems to be no major difference in the suppression of the hypothalamic-pituitary axis in the first cycle on an

OC as compared to subsequent cycles. (PubHealth.info Document ID: CONT2T 4569-06)

PubHealth.info NOTE: The author(s) of this article titled, "Pulsatile luteinizing hormone secretion during the first and

the fourth cycle on two different oral contraceptives containing gestodene.", is(are) Hemrika DJ; Slaats EH;

Kennedy JC; de Vries Robles-Korsen TJ; Schoemaker J. The source of this article is "ACTA ENDOCRINOLOGICA.

1993 Sep;129(3):229-36.". This article was published in 1993 in English language(s). (PubHealth.info® Document

ID: CONT2T 4569-06. All rights reserved with PubHealth.info) PIN: 9569

This article is peer-reviewed.

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