Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1993

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Pharmacokinetics and protein binding of 3-ketodesogestrel and gestodene in

the serum of women during 6 cycles of treatment with two low dose oral

contraceptives.

AUTHORS

Back DJ; Power J; Winkler U; Schindler AE; Daume E; Simon A; Neiss A;

Hammerstein J

SOURCE

ADVANCES IN CONTRACEPTION. 1993 Dec;9(4):319-30.

ABSTRACT

The serum concentrations of 3-ketodesogestrel (KDG) and gestodene have been measured in 30 and 31 women

respectively who took low dose oral contraceptives containing 30 mcg ethinylestradiol together with either 150 mcg

desogestrel or 75 mcg gestodene for 6 months. On days 1, 10, and 21 of the first, third and sixth treatment cycles

blood samples were drawn at 0, 0.5, 1, 1.5, 2, 3, 4 and 24 hours. KDG and gestodene levels were measured by

radioimmunoassay and were evaluated for Cmax (peak serum concentration), tmax (time to Cmax), and AUC (area

under the curve) to 4 and 24 hours. The overall total gestodene concentrations were higher and the accumulation of

the steroid throughout a cycle greater than that of KDG. For example, the AUC0-4 of gestodene increased in cycle 1

by a factor of 2.8 (day 10 vs. day 1) and 3.6 (day 21 vs. day 1) compared to 2.3 and 2.6 for KDG. The higher

concentration of gestodene reflects a lower volume of distribution than KDG, and is consistent with gestodene

binding to sex hormone binding globulin (SHBG) with a higher affinity than KDG. Concentrations of KDG and

gestodene were higher on day 1 of cycles 3 and 6 than on day 1 of cycle 1. The serum concentrations of KDG and

gestodene during multiple dosing cannot be predicted on the basis of single dose pharmacokinetics.

(PubHealth.info Document ID: CONT2T 4564-06)

PubHealth.info NOTE: The author(s) of this article titled, "Pharmacokinetics and protein binding of 3-ketodesogestrel

and gestodene in the serum of women during 6 cycles of treatment with two low dose oral contraceptives.", is(are)

Back DJ; Power J; Winkler U; Schindler AE; Daume E; Simon A; Neiss A; Hammerstein J. The source of this

article is "ADVANCES IN CONTRACEPTION. 1993 Dec;9(4):319-30.". This article was published in 1993 in English

language(s). (PubHealth.info® Document ID: CONT2T 4564-06. All rights reserved with PubHealth.info) PIN: 9564

This article is peer-reviewed.

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