Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1993

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Effect of norethisterone and levonorgestrel in low-dose multiphasic oral

contraceptives on serum lipids.

AUTHORS

Wiik P; Nordby J; Paulsen JE

SOURCE

Acta Obstetrica et Gynecologica Scandinavica. 1993 Oct;72(7):550-5.

ABSTRACT

In a parallel, multicenter study in Norway and Finland involving a total of 196 healthy women (mean age 22.4 years,

range 18-30), the effects on serum lipids and lipoproteins of two multiphasic oral contraceptives (OCs) containing

ethinyl estradiol (EE) but different progestins were examined. One formulation contained EE 35 mcg and

norethisterone (NET) 0.5 mg on days 1-7 and days 17-21 and elevated NET 1.0 mg during the midphase (days 8-16).

The other formulation contained EE 30 mcg on days 1-6 and days 12-21 and 40 mcg on days 7-11 and phased

levonorgestrel (LGN): 50 mcg (days 1-6), 75 mcg (days 7-11) and 125 mcg (days 12-21). Both formulations induced

significant elevation of total cholesterol (6.7 and 4.1%), Apo B (8.1 and 7.0%) as well as HDL (6.4 and 3.7%) for the

EE/NET and EE/LGN formulation respectively. Mean serum levels of triglycerides were significantly elevated (58 and

47%). However, all mean serum lipid and lipoprotein values remained within the normal range, and no change in the

calculated cholesterol ratio (HDL/total cholesterol) nor lipoprotein ratio (HDL/HDL + LDL) was observed. No

significant difference between the formulations could be detected with respect to the effect on serum lipids and

lipoproteins measured. The change in total cholesterol was smaller than reported in many studies of monophasic

preparations. Taken together, these data suggest that only small alterations in lipid metabolism are elicited by these

OCs. (PubHealth.info Document ID: CONT2T 4544-06)

PubHealth.info NOTE: The author(s) of this article titled, "Effect of norethisterone and levonorgestrel in low-dose

multiphasic oral contraceptives on serum lipids.", is(are) Wiik P; Nordby J; Paulsen JE. The source of this article

is "Acta Obstetrica et Gynecologica Scandinavica. 1993 Oct;72(7):550-5.". This article was published in 1993 in

English language(s). (PubHealth.info® Document ID: CONT2T 4544-06. All rights reserved with PubHealth.info) PIN:

9544

This article is peer-reviewed.

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