Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1993

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Differences in the low density lipoprotein subfraction profile between oral

contraceptive users and controls.

AUTHORS

de Graaf J; Swinkels DW; Demacker PN; de Haan AF; Stalenhoef AF

SOURCE

JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. 1993

ABSTRACT

To investigate the effect of low dose oral contraceptives (OCs) on the low density lipoprotein (LDL) subfraction

profile, the distribution of the LDL subfraction patterns in 20 premenopausal women on OC therapy and 41

premenopausal women not taking gonadal hormones was studied. The LDL subfraction patterns were identified by

density gradient ultracentrifugation and each individual LDL subfraction pattern was characterized by the relative

contribution of 3 major LDL subfractions: light, LDL1; intermediate, LDL2; and dense, LDL3 to total LDL. Serum lipid

and lipoprotein levels were similar in OC users and controls, except for significantly higher triglyceride levels in OC

users. As for LDL subfraction patterns, among the OC users the mean relative contribution of dense LDL3 to total

LDL was significantly higher than in the controls (32% +or- 8% vs. 26% +or- 13%, p < 0.05), whereas the relative

contribution of light LDL1 to total LDL was significantly lower (27% +or- 8% vs. 34% +or- 10%, p < 0.01), indicating a

higher prevalence of the more dense LDL subfraction patterns among OC users. Furthermore, the distribution of the

LDL subfraction patterns in OC users (27% LDL1, 43% LDL2, and 33% LDL3, n = 59). Statistical analysis revealed

that OC use was significantly associated with a more dense LDL subfraction pattern, characterized by an increased

relative contribution of LDL3 (+6%, p < 0.05) and a decreased relative contribution of LDL1 (-6%, p < 0.01), even after

correcting for the influence of lipid and lipoprotein levels, which in controls were shown to have a significant relation

to LDL3 and LDL1, respectively. So, independent of the lipid and lipoprotein levels, low dose OC alter the

composition of LDL to a heavy, dense LDL subfraction profile, which reportedly has been associated with an

increased risk of atherosclerosis. (PubHealth.info Document ID: CONT2T 4541-06)

PubHealth.info NOTE: The author(s) of this article titled, "Differences in the low density lipoprotein subfraction profile

between oral contraceptive users and controls.", is(are) de Graaf J; Swinkels DW; Demacker PN; de Haan AF;

Stalenhoef AF. The source of this article is "JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. 1993

Jan;76(1):197-202.". This article was published in 1993 in English language(s). (PubHealth.info® Document ID:

CONT2T 4541-06. All rights reserved with PubHealth.info) PIN: 9541

This article is peer-reviewed.

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