Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1993

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Contact factor mediated fibrinolysis is increased by the combined oral

contraceptive pill.

AUTHORS

Campbell SJ; Mackie IJ; Robinson GE; Machin SJ

SOURCE

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 1993 Jan;100(1):79-84.

ABSTRACT

The objective of this study was to study the fibrinolytic pathways and their relationship with the contact system in

women using combined oral contraceptives (OCs). Serial plasma samples were collected from 18 women before

treatment with combined OCs containing 39 mcg estrogen during treatment cycles 3 and 6, and 2 weeks after

stopping treatment. Fibrinolysis was measured before and after dextran sulphate mediated contact activation using

fibrin plates. Fibrinolysis increased significantly during cycles 3 and 6 (from 77% to 100% and 113%, respectively; p

< 0.01) and showed a further increase after dextran sulphate activation (from 134% to 158% and 267%, respectively; p

< 0.01). Tissue-plasminogen activator, urokinase-plasminogen activator, and plasminogen activator inhibitor did not

change significantly. There were significant elevations of Factor XII (from 0.92 u/ml to 1.43 u/ml; p < 0.01) and

prekallikrein (from 0.94 u/ml to 1.10 u/ml; p < 0.05) in cycle 3, which both remained high at cycle 6 (p < 0.01) and

decreased after stopping the OC. Alpha-2-macroglobulin and C1-esterase inhibitor showed no significant change,

but alpha-1-antitrypsin increased from 0.85 u/ml to 1.11 u/ml by cycle 3 (p < 0.01) and returned to near-normal levels

after stopping the OC. The increase in fibrinolysis may be due to increased levels of Factor XII and prekallikrein

without a corresponding increase in their natural inhibitors (C1-esterase inhibitor and alpha-2-macroglobulin). A

parallel increase in the intrinsic pathway of coagulation may be limited by elevated alpha-1-antitrypsin at the level of

activated Factor XI. The increase in fibrinolysis caused by OCs may balance any potential thrombotic risk due to

increased fibrinogen or vitamin K dependent coagulation factors. (PubHealth.info Document ID: CONT2T 4533-06)

PubHealth.info NOTE: The author(s) of this article titled, "Contact factor mediated fibrinolysis is increased by the

combined oral contraceptive pill.", is(are) Campbell SJ; Mackie IJ; Robinson GE; Machin SJ. The source of this

article is "BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 1993 Jan;100(1):79-84.". This article was

published in 1993 in English language(s). (PubHealth.info® Document ID: CONT2T 4533-06. All rights reserved with

PubHealth.info) PIN: 9533

This article is peer-reviewed.

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