Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1993

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Comparison of a gonadotropin releasing-hormone antagonist plus testosterone

(T) versus T alone as potential male contraceptive regimens.

AUTHORS

Bagatell CJ; Matsumoto AM; Christensen RB; Rivier JE; Bremner WJ

SOURCE

JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. 1993

ABSTRACT

Efforts to develop a hormonal contraceptive regimen for men have focused on administration of testosterone (T),

alone or together with other agents. Previous regimens have successfully induced azoospermia in only 50-70% of

subjects, however. GnRH antagonists, alone or in combination with T, have been shown to induce azoospermia in a

very high percentage of nonhuman primates. The authors tested the hypothesis that the addition of a GnRH

antagonist to a high-dose T regimen would lead to a higher percentage of men developing azoospermia than would T

alone. The authors administered the GnRH antagonist, Nal-Glu (100 mcg/kg/day sc), plus T enanthate, 200 mg im

weekly or placebo sc in injections daily plus T enanthate, 200 mg im weekly, to separate groups of healthy men for

16-20 weeks. 7 of 10 men who received Nal-Glu plus T and 6 and 9 men who received T alone became

azoospermic; gonadotropin levels were suppressed and T levels were increased similarly in both groups. There was

a trend toward higher pretreatment gonadotropin levels and lower sperm counts in men who became azoospermic.

Weight gain, development of acne, and increases in hematocrit and hemoglobin were similar in the 2 groups. In the

majority of the men, sperm counts returned to the baseline levels within 4-5 months after treatment ended. The

authors conclude that with the dosages of Nal-Glu and T they used in this study, the addition of GnRH antagonist to

a high-dose T regimen does not increase the ability of T to suppress spermatogenesis in healthy men. Use of a

higher dose of Nal-Glu, a lower dose of T, delaying the start of T replacement until several weeks after Nal-Glu

injections are initiated, or prolonged hormonal administration might lead to a combination regimen that will suppress

spermatogenesis more fully than does T along. (PubHealth.info Document ID: CONT2T 4532-06)

PubHealth.info NOTE: The author(s) of this article titled, "Comparison of a gonadotropin releasing-hormone

antagonist plus testosterone (T) versus T alone as potential male contraceptive regimens.", is(are) Bagatell CJ;

Matsumoto AM; Christensen RB; Rivier JE; Bremner WJ. The source of this article is "JOURNAL OF CLINICAL

ENDOCRINOLOGY AND METABOLISM. 1993 Aug;77(2):427-32.". This article was published in 1993 in English

language(s). (PubHealth.info® Document ID: CONT2T 4532-06. All rights reserved with PubHealth.info) PIN: 9532

This article is peer-reviewed.

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