Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1995

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis

associated with oral contraceptives containing a third-generation

progestagen.

AUTHORS

Bloemenkamp KW; Rosendaal FR; Helmerhorst FM; Buller HR; Vandenbroucke

SOURCE

Lancet. 1995 Dec 16;346(8990):1593-6.

ABSTRACT

In the Netherlands, researchers compared data on 126 women with deep-vein thrombosis (DVT) with data on 159

premenopausal women aged 15-49 to examine the risk of DVT during use of oral contraceptives (OCs) containing a

third generation progestogen as well as the influence of the thrombogenic factor V Leiden mutation, family history of

thrombosis, age, and previous pregnancy. The desogestrel-containing monophasic OC had the highest relative risk

for DVT (8.7 vs. 2.2-3.8). There were too few women using OCs containing gestodene or norgestimate to draw

substantial conclusions. The OC with 30 mcg ethinyl estradiol (E2) and desogestrel increased the risk of DVT 2.2

times when compared with the levonorgestrel-containing OC with the same amount of E2. When compared with all

other OCs, desogestrel-containing OCs had a 2.5 higher risk. When the researchers compared carriers of the factor

V Leiden mutation with non-carriers, the risk of DVT increased about 50 times among women using desogestrel-

containing OCs. The age-adjusted relative risk of DVT for desogestrel-containing OCs was 7.2. Even though a

positive family history of DVT and factor V Leiden mutation enhanced the effect of desogestrel-containing Ocs,

neither could account for all the excess risk of the desogestrel-containing OC since the risk of DVT increased in

women with and without a family history of DVT and those with and without factor V Leiden. These findings suggest

that the OCs containing a third-generation progestogen (i.e., desogestrel) contribute to a reverse of the gains

achieved in reducing the thrombotic risk by decreasing the dose of E2. (PubHealth.info Document ID: CONT2T 2590-

06)

PubHealth.info NOTE: The author(s) of this article titled, "Enhancement by factor V Leiden mutation of risk of deep-

vein thrombosis associated with oral contraceptives containing a third-generation progestagen.", is(are)

Bloemenkamp KW; Rosendaal FR; Helmerhorst FM; Buller HR; Vandenbroucke JP. The source of this article is

"Lancet. 1995 Dec 16;346(8990):1593-6.". This article was published in 1995 in English language(s).

(PubHealth.info® Document ID: CONT2T 2590-06. All rights reserved with PubHealth.info) PIN: 7590

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