Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1995

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Effect of two oral contraceptives containing ethinylestradiol and gestodene

or norgestimate upon androgen parameters and serum binding proteins.

AUTHORS

Wiegratz I; Jung-Hoffmann C; Kuhl H

SOURCE

CONTRACEPTION. 1995 Jun;51(6):341-6.

ABSTRACT

At the J. W. Goethe University Hospital in Frankfurt am Main, Germany, researchers randomly allocated 46 women to

use either the triphasic oral contraceptive (OC) containing 30 mcg ethinyl estradiol (EE) and 50 mcg gestodene or the

monophasic OC containing 35 mcg EE and 250 mcg norgestimate. They wanted to compare the effects of the two

OCs on different serum hormonal parameters and serum binding proteins. Health workers took blood samples from

the women on days 2, 11, and 21 of the cycle before OC use and of treatment cycles 3, 6, and 12. The two groups

had similar hormonal parameters. Both OCs suppressed serum levels of dehydroepiandrosterone sulphate (DHEA-S)

by 20-30% (p < 0.01). They reduced 5alpha-androstane-3alpha, 17beta-diol glucuronide by 50-60% (p < 0.01) during

each treatment cycle. Both OCs also reduced androstenedione serum levels by 25% (p < 0.01). Both OCs reduced

serum levels of total testosterone by about 30% and of free testosterone by 60% (p < 0.01-0.05 and p < 0.01,

respectively). The 200% increase of serum levels of sex hormone binding globulin (SHBG) on days 11 and 21 of each

cycle in both groups (p < 0.01) caused the more pronounced decrease of serum levels of free testosterone.

Suppression of ovarian androgen synthesis also contributed to the more pronounced decrease of free testosterone.

SHBG levels fell during the pill-free interval but remained 100% higher than pretreatment values. Serum levels of

corticosteroid binding globulin (CBG) increased by 170% during each treatment cycle (p < 0.01). CBG levels fell

during the pill-free interval, but remained higher by 90-100% than the pretreatment cycle. Only the estrogenic

component affected the increase in CBG. Both OCs increased cortisol serum levels by 110-140% (p < 0.01). These

findings show that both OCs significantly suppressed some androgen parameters and peripheral androgen

metabolism. (PubHealth.info Document ID: CONT2T 2561-06)

PubHealth.info NOTE: The author(s) of this article titled, "Effect of two oral contraceptives containing ethinylestradiol

and gestodene or norgestimate upon androgen parameters and serum binding proteins.", is(are) Wiegratz I; Jung-

Hoffmann C; Kuhl H. The source of this article is "CONTRACEPTION. 1995 Jun;51(6):341-6.". This article was

published in 1995 in English language(s). (PubHealth.info® Document ID: CONT2T 2561-06. All rights reserved with

PubHealth.info) PIN: 7561

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