Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1995

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Development of contraceptive vaccines for humans using antigens derived from

gametes (spermatozoa and zona pellucida) and hormones (human chorionic

gonadotrophin): current status.

AUTHORS

Naz RK; Sacco A; Singh O; Pal R; Talwar GP

SOURCE

HUMAN REPRODUCTION UPDATE. 1995 Jan;1(1):1-18.

ABSTRACT

Contraceptive research has entered a new phase of development with the advent of hybridoma and DNA recombinant

technologies. During the past 5 years, significant advances have been made in this area, and now it seems that

realistic prospects exist for the development of contraceptive vaccines for use in humans and animals (veterinary,

wild and domestic), applicable to both the female and male sexes. Contraceptive vaccines will be valuable

supplements to the presently available methods of family planning, and, due to high specificity, the occurrence of

limited side-effects, if any, low cost and infrequent administration, contraceptive vaccines may have greater

acceptability than the currently available methods. Mammalian reproduction starts with the unison of gametes

contributed by the male and female partners. Both spermatozoon and oocyte have antigens on the cell surface that

are unique, tissue-specific, immunogenic and accessible to antibodies, and binding of the antibodies to these

antigens can cause inhibition of gamete function, resulting in a failure of fertilization. Fertilization is followed by

embryogenesis, with the early embryo producing several proteins, some of which, e.g., human chorionic gonadotropin

(HCG), have a vital role in the establishment and maintenance of early pregnancy. Again, these proteins are

accessible to antibodies, and their immunoneutralization can cause anti-fertility effects with loss of early embryos.

Thus, the antigens derived from proteins on spermatozoa, oocyte and early embryo, especially HCG, constitute

interesting molecules for the development of contraceptive vaccines. The aim of the present article is to review the

current status of development of contraceptive vaccines based on antigens derived from sperm cell, oocyte zona

pellucida and HCG, and to discuss their relative merits and future development. (PubHealth.info Document ID:

CONT2T 2536-06)

PubHealth.info NOTE: The author(s) of this article titled, "Development of contraceptive vaccines for humans using

antigens derived from gametes (spermatozoa and zona pellucida) and hormones (human chorionic gonadotrophin):

current status.", is(are) Naz RK; Sacco A; Singh O; Pal R; Talwar GP. The source of this article is "HUMAN

REPRODUCTION UPDATE. 1995 Jan;1(1):1-18.". This article was published in 1995 in English language(s).

(PubHealth.info® Document ID: CONT2T 2536-06. All rights reserved with PubHealth.info) PIN: 7536

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