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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1995

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Decreased bone turnover in oral contraceptive users.

AUTHORS

Garnero P; Sornay-Rendu E; Delmas PD

SOURCE

BONE. 1995 May;16(5):499-503.

ABSTRACT

The objective of this study was to determine the effect of oral contraceptives (OCs) on bone turnover. The design

consisted of a cross-sectional analysis of a prospective cohort. There were 52 women taking OCs and 156 nonuser

controls from a large cohort of 1039 healthy women, aged 31-89 years (OFELY study). Most users were taking

combined OCs containing 30 mcg ethinyl estradiol and the mean duration of pill use was 6.7 +or- 6.4 years. Users

and nonusers were matched for age (mean age [years]: 39.3 +or- 3.5 vs. 40.5 +or- 4.3; range 35-49 years for both).

Main outcome measures included three markers of bone formation (serum osteocalcin, bone-specific alkaline

phosphatase, and C-terminal propeptide of type I collagen) and two markers of bone resorption that are pyridinoline

crosslinked peptides (Cross-laps and NTX). Users and nonusers did not differ for weight, height, alcohol and

tobacco use, dietary calcium intake, parity, exercise activity, body fat and lean composition, and calcium chemistry

tests. In pill users all bone formation and resorption markers were decreased compared with controls: osteocalcin,

7.7 +or- 2.7 vs. 10.1 +or- 3.1 ng/ml (-24%, p < 0.001); bone-specific alkaline phosphatase, 7.5 +or- 2.3 vs. 8.8 +or- 2.7

ng/ml (-15%, p < 0.003); C-terminal propeptide of type I collagen, 77.2 +or- 93.1 vs. 93.1 +or- 31.9 ng/ml (-17%, p =

0.001); Crosslaps, 175 +or- 91 vs. 211 +or- 105 mcg/mmol Cr (-17%, p = 0;03); and NTX, 16.2 +or- 5.9 vs. 22.5 +or-

9.4 nmol of bone collagen equivalent/mmol Cr (-28%, p < 0.001). There was no significant difference in whole body

BMC and BMD, lumbar spine, total hip, and distal radius BMD between OC users and controls. Oral contraception is

associated with a moderate, but significant, decrease in bone turnover that may have a beneficial influence on bone

mass only, after prolonged use. However, given the large interindividual variability of bone mass, such an effect

could not be established by this cross-sectional study and a longitudinal design is required. (PubHealth.info

Document ID: CONT2T 2516-06)

PubHealth.info NOTE: The author(s) of this article titled, "Decreased bone turnover in oral contraceptive users.",

is(are) Garnero P; Sornay-Rendu E; Delmas PD. The source of this article is "BONE. 1995 May;16(5):499-503.".

This article was published in 1995 in English language(s). (PubHealth.info® Document ID: CONT2T 2516-06. All

rights reserved with PubHealth.info) PIN: 7516

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