Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1996

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

The role of thromboxane A2 in increased whole blood platelet aggregation in

oral contraceptive users.

AUTHORS

Norris LA; Devitt M; Bonnar J

SOURCE

THROMBOSIS RESEARCH. 1996 Feb 15;81(4):407-17.

ABSTRACT

In Ireland, researchers randomly assigned 44 healthy women, 18-34 years old, to either the group using the oral

contraceptive (OC) containing 30 mcg ethinyl estradiol (EE) and 150 mcg desogestrel (Marviol) or the group using the

OC containing 30 mcg EE and 75 mcg gestodene (Femodene) to determine the progestogen's modifying effect on

whole blood platelet aggregation. In vitro, they incubated the platelets with aspirin and a thromboxane synthetase

inhibitor (dazmegrel) to examine the role of thromboxane (TXA2) in any increased aggregation. The women were

recruited from the postnatal clinic of the Coombe Women's Hospital in Dublin. OC use caused a significant

increase in collagen-, arachidonic acid- (AA), and ADP-induced whole blood platelet aggregation (p < 0.03, < 0.001,

and < 0.01, respectively). It had no effect on PAF-induced aggregation, however. No significant differences in

platelet aggregation levels existed between gestodene and desogestrel. Both aspirin and dazmegrel had a

significant inhibitory effect on OC-induced increase in platelet aggregation in terms of collagen, AA, and ADP. This

suggests that OCs act synergistically with ADP to cause a TXA2 mediated increase in platelet aggregation.

Dazmegrel, but not aspirin, caused a decrease in PAF-induced platelet aggregation in the desogestrel/30 mcg EE

group only, suggesting a possible difference in the modifying effects of the 2 progestogens, which is revealed when

thromboxane synthetase is inhibited. Dazmegrel's inhibitory effect suggests that increased thromboxane synthetase

activity plays a role in the OC-induced platelet hyperactivity. Changes in the TXA2/prostacyclin ratio appear to

mediate OCs' effect on platelet aggregation. (PubHealth.info Document ID: CONT2T 2087-06)

PubHealth.info NOTE: The author(s) of this article titled, "The role of thromboxane A2 in increased whole blood

platelet aggregation in oral contraceptive users.", is(are) Norris LA; Devitt M; Bonnar J. The source of this article is

"THROMBOSIS RESEARCH. 1996 Feb 15;81(4):407-17.". This article was published in 1996 in English language(s).

(PubHealth.info® Document ID: CONT2T 2087-06. All rights reserved with PubHealth.info) PIN: 7087

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