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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.





YEAR: 1996




CATEGORY: Contraception (Birth Control) and Family Planning



TITLE



Risk for ovulation in women taking a low-dose oral contraceptive

(Microgynon) when receiving antibacterial treatment with a fluoroquinolone

(ofloxacin)



AUTHORS

Csemiczky G; Alvendal C; Landgren BM


SOURCE

ADVANCES IN CONTRACEPTION. 1996 Jun;12(2):101-9.



ABSTRACT

In the division of obstetrics and gynecology of Karolinska Hospital in Stockholm, Sweden, physicians conducted a

prospective, randomized, double-blind, crossover study among 20 healthy women aged 21-40 with regular menstrual

cycles. They aimed to evaluate a possible risk of escape ovulation in women using a combined oral contraceptive

(OC) (150 mcg levonorgestrel + 30 mcg ethinyl estradiol) (Microgynon, Schering AG) during treatment with ofloxacin

(Tarivid, Hoechst AG, Germany) for 7 days. One woman had to be excluded from the study because she had to be

treated with erythromycin due to pneumonia. The women were advised to use a mechanical contraceptive method

during the study period. Laboratory personnel measured follicle stimulating hormone and estradiol levels on tablet

days 5-8 and 19-21 and progesterone on days 19-21 during treatment with ofloxacin or placebo. Medical personnel

conducted ultrasound on one of days 5-10, 11-17, 18-24, and 25-28 to measure the number and diameter of ovarian

follicles. There was no evidence of escape ovulation during ofloxacin treatment. High estradiol levels up to 600

pmol/l in conjunction with ovarian follicles of 15 mm or higher without any increase in progesterone levels above 3

nmol/l occurred in four women. This ovarian activity with no escape ovulation occurred during placebo and ofloxacin

treatment, suggesting that interaction between the OC and ofloxacin did not account for the ovarian activity. In

conclusion, OC users on ofloxacin medication do not need to use other contraceptives during ofloxacin treatment.

(PubHealth.info Document ID: CONT2T 2074-06)



PubHealth.info NOTE: The author(s) of this article titled, "Risk for ovulation in women taking a low-dose oral

contraceptive (Microgynon) when receiving antibacterial treatment with a fluoroquinolone (ofloxacin)", is(are)

Csemiczky G; Alvendal C; Landgren BM. The source of this article is "ADVANCES IN CONTRACEPTION. 1996

Jun;12(2):101-9.". This article was published in 1996 in English language(s). (PubHealth.info® Document ID:

CONT2T 2074-06. All rights reserved with PubHealth.info) PIN: 7074





 

 

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