Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1997

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

A randomized cross-over study comparing pharmacodynamic and metabolic

variables of a new combiphasic and a well-established triphasic oral

contraceptive.

AUTHORS

van den Ende A; Geurts TB; Kloosterboer HJ

SOURCE

EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH

CARE. 1997 Sep;2(3):173-80.

ABSTRACT

The newly developed combiphasic oral contraceptive (OC) Gracial has a step-up/step-down sequence in which the

daily progestogen (desogestrel) dose increases while the daily ethinyl estradiol dose decreases during the second

phase of the pill cycle. In addition, the standard 7-day pill-free interval is reduced to 6 days to lower the risk of

significant follicular development. The short-term effects of this combiphasic OC and a triphasic OC with a

comparable ethinyl estradiol dose but a different progestogen (levonorgestrel) on selected pharmacodynamic and

metabolic parameters were evaluated in an open-label cross-over study involving 20 women. Both formulations

adequately and similarly inhibited ovulation; however, the combiphasic OC induced higher increases in plasma

carrier proteins and a potentially more favorable plasma lipid profile than the triphasic. There were no differences

between OCs in terms of fasting glucose and insulin, glycosylated proteins, and antithrombin III activity. The

combiphasic OC showed significantly higher plasma levels than the triphasic of estrogen-dependent lipid

parameters such as triglycerides, high density lipoprotein-cholesterol, and apolipoprotein A1 and significantly lower

levels of low density lipoprotein-cholesterol and apolipoprotein B. (PubHealth.info Document ID: CONT2T 1031-06)

PubHealth.info NOTE: The author(s) of this article titled, "A randomized cross-over study comparing

pharmacodynamic and metabolic variables of a new combiphasic and a well-established triphasic oral

contraceptive.", is(are) van den Ende A; Geurts TB; Kloosterboer HJ. The source of this article is "EUROPEAN

JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE. 1997 Sep;2(3):173-80.". This article was

published in 1997 in English language(s). (PubHealth.info® Document ID: CONT2T 1031-06. All rights reserved with

PubHealth.info) PIN: 6031

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