Contraception (Birth Control) and Family Planning PubHealthInfo

[PubHealth.info Homepage] [Category Homepage] [Disclaimer/Copyrights] [Feedback]

Thank you for your kind visit to PubHealth.info®, an information portal created in technical collaboration with PakMed Biomedical Solutions * * * PubHealth.info® presents hundreds of thousands of informative Web pages on a variety of public health issues / issues * * * An ultimate source of information for teachers, students and research workers who need to find information on various public health issues, like population planning, contraception, HIV AIDS, STDs, maternal and child health, communicable and non-communicable disease, etc. * * * PubHealth.info® regularly updates the repository of these hundreds of thousands of informative Web pages * * * PubHealth.info® is one of the world's largest repositories and information portals with online Web pages on public health issues particularly those pertaining to developing countries!

PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2005

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Association between the current use of low-dose oral contraceptives and

cardiovascular arterial disease: a meta-analysis.

AUTHORS

Baillargeon JP; McClish DK; Essah PA; Nestler JE

SOURCE

Journal of Clinical Endocrinology and Metabolism. 2005 Jul;90(7):3863-3870.

ABSTRACT

The long-term cardiovascular safety of widely used oral contraceptives (OCs) is still debated, and no meta-analysis

assesses the modern use of OCs and the associated cardiovascular risks. We aimed to assess the risk of

cardiovascular diseases associated with current use of low-dose combined OCs. All studies published between

January 1980 and October 2002 were searched using MEDLINE, BIOSIS, and Scientific Citations. Original studies

were selected independently by two investigators (J.P.B., P.A.E.) based on inclusion criteria: low-dose combined OC

(< 50 µg of ethinyl-estradiol); more than 10 cases in low-dose users; clear definition of cases; concurrent controls;

and control for age. A third investigator (J.E.N.) adjudicated disagreements. From 2715 identified articles, 14

independent studies were included. All data were abstracted by one investigator (J.P.B.) in a systematic manner.

Classification of OCs and types of exposure were directly abstracted from studies. Current use was defined as use at

the time of the event or within 3 months. Only peer-reviewed studies with definition of events as definite or possible,

based on prespecified criteria, were included. The summary risk estimates associated with current use of low-dose

OCs were 1.84 [95% confidence interval (CI) = 1.38, 2.44] for myocardial infarctions and 2.12 (95% CI =1.56, 2.86) for

ischemic strokes. The overall summary odds ratio for both outcomes was 2.01 (95% CI =1.63, 2.48). Second

generation OCs were associated with a significant increased risk of both myocardial infarction and ischemic stroke

events [1.85 (95% CI =1.03, 3.32) and 2.54 (95% CI_1.96, 3.28), respectively]; and third-generation OCs, for ischemic

stroke outcome only [2.03 (95% CI =1.15, 3.57)]. In conclusion, a rigorous meta-analysis of the literature suggests

that current use of low-dose OCs significantly increases the risk of both cardiac and vascular arterial events,

including a significant risk of vascular arterial complications with third generation OCs. (PubHealth.info Document

ID: CONT1T 67-06)

PubHealth.info NOTE: The author(s) of this article titled, "Association between the current use of low-dose oral

contraceptives and cardiovascular arterial disease: a meta-analysis.", is(are) Baillargeon JP; McClish DK; Essah

PA; Nestler JE. The source of this article is "Journal of Clinical Endocrinology and Metabolism. 2005

Jul;90(7):3863-3870.". This article was published in 2005 in English language(s). (PubHealth.info® Document ID:

CONT1T 67-06. All rights reserved with PubHealth.info) PIN: 67

This article is peer-reviewed.

This page is optimized to be viewed by Java script enabled Microsoft® Internet Explorer 6 or later version, at screen resolution of 800 by 600 pixels.