Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2005

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Angiogenic effects of Norplant contraception on endometrial histology and

uterine bleeding.

AUTHORS

Pritts EA; Ryan IP; Mueller MD; Lebovic DI; Shifren JL

SOURCE

Journal of Clinical Endocrinology and Metabolism. 2005 Apr;90(4):2142-2147.

ABSTRACT

Norplant, a sc contraceptive device, releases levonorgestrel in a sustained fashion. Its effectiveness is offset by

irregular bleeding patterns. Because vascular endothelial growth factor (VEGF) is stimulated by synthetic

progestogens in vitro and in vivo, we postulated that correlations between this angiogenic factor and uterine bleeding

patterns might exist. Twenty-eight women who were exposed to Norplant and 13 control women were prospectively

followed for 6-8 months. Bleeding diaries were collected, hysteroscopies were performed, endometrial biopsies were

obtained for standardized histological evaluation, and VEGF histochemical immunostaining (H)-scores were

assigned. Cluster determination-34 (CD34) staining was also performed to quantify the number of endometrial blood

vessels per high-power field. Irregular uterine bleeding was common among women using Norplant devices.

Endometrial VEGF H-scores were greater in women using Norplant than in control women. New findings of this study

show that vessel density did not correlate with epithelial VEGF H-scores but was highly associated with the intensity

of stromal and perivascular VEGF. VEGF expression in the latter regions correlated significantly with hysteroscopic

abnormalities and irregular bleeding. The expression of this angiogenic protein, particularly in the stromal and

perivascular compartments, correlated with microvascular density, hysteroscopically documented hypervascularity,

and uterine bleeding profiles. Irregular bleeding with Norplant use appears to reflect paracrine-mediated effects on

vascular function by angiogenic factors, such as VEGF. (PubHealth.info Document ID: CONT1T 64-06)

PubHealth.info NOTE: The author(s) of this article titled, "Angiogenic effects of Norplant contraception on

endometrial histology and uterine bleeding.", is(are) Pritts EA; Ryan IP; Mueller MD; Lebovic DI; Shifren JL. The

source of this article is "Journal of Clinical Endocrinology and Metabolism. 2005 Apr;90(4):2142-2147.". This article

was published in 2005 in English language(s). (PubHealth.info® Document ID: CONT1T 64-06. All rights reserved

with PubHealth.info) PIN: 64

This article is peer-reviewed.

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