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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.





YEAR: 2004




CATEGORY: Contraception (Birth Control) and Family Planning



TITLE



Male hormonal contraception: effects of injections of testosterone

undecanoate and depot medroxyprogesterone acetate at eight-week intervals in

Chinese men.



AUTHORS

Gu YQ; Tong JS; Ma DZ; Wang XH; Yuan D


SOURCE

Journal of Clinical Endocrinology and Metabolism. 2004 May;89(5):2254-2262.



ABSTRACT

Surveys indicate that one form of acceptable male hormonal contraception would consist of injections given at 2- to

3-month intervals. This report describes a study of depot medroxyprogesterone acetate (DMPA) and testosterone

undecanoate (TU) injected at 8-wk intervals for suppression of spermatogenesis in healthy Chinese men. After

screening, 30 healthy volunteers were enrolled and randomly assigned to one of three dose groups (n =

10/group):1000 mg TU (group A); 1000 mg TU plus 150 mg DMPA (group B); 1000 mg TU plus 300 mg DMPA (group

C). All doses were given as im injections at 8-wk intervals. The study consisted of an 8-wk control (baseline) period,

a 24-wk treatment period, and a 24-wk recovery period. Consistent azoospermia or severe oligozoospermia was

achieved and maintained in all volunteers during the treatment period, except for two men in the TU-alone group who

experienced a rebound in sperm concentrations. An 8-wk regimen of TU plus DMPA at both tested combination

doses effectively suppressed spermatogenesis to azoosermia in Chinese men. All volunteers tolerated the

injections; no serious adverse effects were reported. The lower-dose combination is recommended for further testing

in an expanded clinical trial or contraceptive efficacy study. (PubHealth.info Document ID: CONT1T 582-06)



PubHealth.info NOTE: The author(s) of this article titled, "Male hormonal contraception: effects of injections of

testosterone undecanoate and depot medroxyprogesterone acetate at eight-week intervals in Chinese men.", is(are)

Gu YQ; Tong JS; Ma DZ; Wang XH; Yuan D. The source of this article is "Journal of Clinical Endocrinology and

Metabolism. 2004 May;89(5):2254-2262.". This article was published in 2004 in English language(s).

(PubHealth.info® Document ID: CONT1T 582-06. All rights reserved with PubHealth.info) PIN: 582


This article is peer-reviewed.




 

 

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