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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2004

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Interleukin-6 and antiphospholipid antibodies in women with contraceptive-

related thromboembolic disease.

AUTHORS

Salobir B; Sabovic M

SOURCE

Obstetrics and Gynecology. 2004 Sep;104(3):564-570.

ABSTRACT

Objective: The aim of this study was to explore the possible (joint) contributing role of interleukin-6 (IL-6) and

antiphospholipid antibodies to the occurrence of the venous thromboembolism in women using oral contraceptives.

Methods: Interleukin-6 and antiphospholipid antibodies (anti-ß2-glycoprotein I antibody-immunoglobulin M [IgM], G

[IgG], and A [IgA]; anticardiolipin-IgM and IgG; antiphosphatidylserine-IgM and IgG) were measured in 30 women

(median age 41, range 28-49 years) in the stable period (on average 3.5 years) after first venous thromboembolism.

Sixteen patients used oral contraceptives during the episode of venous thromboembolism (oral contraceptives

group), whereas 14 patients did not (non-oral contraceptives group). Thirty-seven age-matched, healthy women served

as controls. Results: Compared with controls, the oral contraceptives group had elevated IL-6 (median interquartile

range 2.3 [1.1-4.3] versus 1.4 [0-2.0] pg/mL, P < .05). The oral contraceptives group had elevated anti-ß2-glycoprotein

I antibody-IgM in comparison with both the non-oral contraceptives group (median interquartile range 47.5 [2.0-77.0]

versus 29.50 [11.00-45.50] OD450, P < .06) and controls (47.5 [2.0-77.0] versus 17.5 [3.5- 30.0] OD450, P < .001).

Interleukin-6 level in the non-oral contraceptives group was related to obesity, whereas such a relation was not found

in the oral contraceptives group, suggesting the presence of another factor (oral contraceptive use), which stimulates

IL-6 production. Of particular interest is our finding that elevated IL-6 levels correlated significantly positively with

elevated anti-ß2-glycoprotein I antibody-IgG in patients who were users of oral contraceptives (but not overweight, n =

10) (r = 0.56, P < .05). Conclusion: The results suggest a new hypothesis that, in susceptible women, use of oral

contraceptives induces production of IL-6, which stimulates production of anti- ß2-glycoprotein I. Thus, the

prothrombotic profile is aggravated and could facilitate occurrence of venous thromboembolism. This remains to be

elucidated in further studies. (PubHealth.info Document ID: CONT1T 573-06)

PubHealth.info NOTE: The author(s) of this article titled, "Interleukin-6 and antiphospholipid antibodies in women

with contraceptive-related thromboembolic disease.", is(are) Salobir B; Sabovic M. The source of this article is

"Obstetrics and Gynecology. 2004 Sep;104(3):564-570.". This article was published in 2004 in English language(s).

(PubHealth.info® Document ID: CONT1T 573-06. All rights reserved with PubHealth.info) PIN: 573

This article is peer-reviewed.

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