Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2004

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

The impact of improved compliance with a weekly contraceptive transdermal

system (Ortho Evra) on contraceptive efficacy.

AUTHORS

Archer DF; Cullins V; Creasy GW; Fisher AC

SOURCE

Contraception. 2004 Mar;69(3):189-195.

ABSTRACT

The contraceptive efficacy of perfect dosing cycles and imperfect dosing cycles has not been described previously.

Method compliance determines the proportion of perfect and imperfect dosing cycles, and together can form the

basis for evaluating differences in efficacy based on differences in compliance. The transdermal contraceptive

delivery system (Ortho Evra) has been studied in a North American randomized trial vs. an oral contraceptive (OC) and

in total has been evaluated in 3319 women in contraceptive clinical trials. This article explores the impact of perfect

vs. imperfect compliance with the contraceptive method on contraceptive efficacy. Previously published data for a

transdermal system (Patch, n = 812) and OC (Triphasil, n = 605) users from the North American comparative study

were reanalyzed to determine the effect of imperfect use on the contraceptive efficacy of the different methods.

Contraceptive efficacy was significantly better (p = 0.007) in cycles with perfect dosing (Pearl Index = 0.83) compared

to those with imperfect dosing (Pearl Index = 6.32) for both methods. This difference is homogeneous (p = 0.62)

across the Patch and OC groups. Pooled data for all Patch users confirm that perfect dosing cycles are associated

with significantly better efficacy than imperfect dosing cycles (p = 0.047). In addition, compliance did not vary by age

in the pooled Patch data, which are in agreement with the previously published Patch data from the comparative

study. In the comparative study, the percentage of cycles with perfect dosing was significantly higher with the Patch

than with the OC (88.7% vs. 79.2%, p < 0.001), and was consistently high in all age groups (range, 89.6 -91.8%). By

contrast, among OC users, the percentage of cycles with perfect dosing increased with increasing age (p < 0.001)

from 67.7% in users aged 18 -20 years to more than 80% in those aged 30 years and older. In conclusion, deviations

from perfect use (whether corrected or not) of a transdermal contraceptive system and of an OC increase

contraceptive failures by approximately 5-10-fold when compared to perfect use. The weekly change schedule of the

transdermal contraceptive delivery system is associated with a significantly greater proportion of cycles in which

there is perfect dosing compared to an OC. (PubHealth.info Document ID: CONT1T 571-06)

PubHealth.info NOTE: The author(s) of this article titled, "The impact of improved compliance with a weekly

contraceptive transdermal system (Ortho Evra) on contraceptive efficacy.", is(are) Archer DF; Cullins V; Creasy GW;

Fisher AC. The source of this article is "Contraception. 2004 Mar;69(3):189-195.". This article was published in

2004 in English language(s). (PubHealth.info® Document ID: CONT1T 571-06. All rights reserved with

PubHealth.info) PIN: 571

This article is peer-reviewed.

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