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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.





YEAR: 2004




CATEGORY: Contraception (Birth Control) and Family Planning



TITLE



Flutamide-metformin plus an oral contraceptive (OC) for young women with

polycystic ovary syndrome: switch from third- to fourth-generation OC

reduces body adiposity.



AUTHORS

Ibáñez L; de Zegher F


SOURCE

Human Reproduction. 2004;19(8):1725-1727.



ABSTRACT

Low-dose flutamide-metformin has been developed as a background therapy for non-obese adolescents and young

women with hyperinsulinaemic hyperandrogenism, a variant of polycystic ovary syndrome (PCOS). We verified

whether the lipolytic efficacy of flutamide-metformin in women with PCOS is enhanced by giving an oral contraceptive

(OC) co-therapy that contains drospirenone, instead of gestodene, as progestin. An open-labelled study was carried

out in which non-obese women with PCOS (n = 29; age -20 years), who had been on a combination of flutamide (62.5

mg/day), metformin (850 mg/day) and ethinylestradiol-gestodene for 8-15 months, were randomized for replacement

of the gestodene OC by a drospirenone OC. Assessments of endocrine-metabolic state and body composition (by

dual-energy X-ray absorptiometry) were performed at randomization and after 6 months. The switch to drospirenone

OC was accompanied by a reduction of total and abdominal fat (mean -0.8 and -0.5 kg) and by an increment of lean

body mass (10.6 kg; all P < 0.01), so that body adiposity was strikingly reduced without changing body weight. In

nonobese women with PCOS, low-dose flutamide-metformin reduces total and abdominal fat excess more effectively

if contraceptive co-therapy contains drospirenone, instead of gestodene, as progestin. (PubHealth.info Document ID:

CONT1T 562-06)



PubHealth.info NOTE: The author(s) of this article titled, "Flutamide-metformin plus an oral contraceptive (OC) for

young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity.",

is(are) Ibáñez L; de Zegher F. The source of this article is "Human Reproduction. 2004;19(8):1725-1727.". This

article was published in 2004 in English language(s). (PubHealth.info® Document ID: CONT1T 562-06. All rights

reserved with PubHealth.info) PIN: 562


This article is peer-reviewed.




 

 

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