Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2004

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Ex vivo analysis of HIV-1 co-receptors at the endocervical mucosa of women

using oral contraceptives.

AUTHORS

Prakash M; Patterson S; Gotch F; Kapembwa MS

SOURCE

BJOG: an International Journal of Obstetrics and Gynaecology. 2004

ABSTRACT

Combined oral contraceptives may alter the microenvironment of the female genital tract and, thus, influence

susceptibility of endocervical cells to HIV-1 transmission. The mechanism for this effect is unknown but might

involve combined oral contraceptive up-regulation of chemokine receptors on CD4+ endocervical cells. We measured

chemokine co-receptor (CCR5 and CXCR4) expression on cervical intraepithelial CD4+ T lymphocytes,

macrophages and dendritic cells using flow cytometry in 32 healthy women, 16 of whom were combined oral

contraceptive users and 16 non-users. All women tested negative for sexually transmitted infections. Combined oral

contraceptive users showed a higher proportion of CCR5+ CD4+ T lymphocytes compared with combined oral

contraceptive non-users (P < 0.05). However, expression of both co-receptors on cervical intraepithelial macrophages

and dendritic cells was no different between the two groups. Up-regulation of CCR5 on cervical intraepithelial CD4+

T lymphocytes offers a potential explanation by which women receiving combined oral contraceptives may be at

increased risk of HIV transmission. (PubHealth.info Document ID: CONT1T 553-06)

PubHealth.info NOTE: The author(s) of this article titled, "Ex vivo analysis of HIV-1 co-receptors at the endocervical

mucosa of women using oral contraceptives.", is(are) Prakash M; Patterson S; Gotch F; Kapembwa MS. The

source of this article is "BJOG: an International Journal of Obstetrics and Gynaecology. 2004 Dec;111:1468-1470.".

This article was published in 2004 in English language(s). (PubHealth.info® Document ID: CONT1T 553-06. All

rights reserved with PubHealth.info) PIN: 553

This article is peer-reviewed.

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