Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2005

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

A 1-year study to compare the hemostatic effects of oral contraceptive

containing 20 micrograms of ethinylestradiol and 100 micrograms of

levonorgestrel with 30 micrograms of ethinylestradiol and 100 micrograms of

levonorgestrel.

AUTHORS

Jespersen J; Endrikat J; Düsterberg B; Schmidt W; Gerlinger C

SOURCE

Contraception. 2005;72:98-104.

ABSTRACT

Objectives: To comparatively evaluate the impact of a balanced one- third dose-reduced oral contraceptive on

hemostatic variables. Methods: In an open-label, randomized study, a dose-reduced oral contraceptive containing 20

µg of ethinylestradiol (EE) and 100 µg of levonorgestrel (LNG) was compared with a reference preparation containing

30 µg of EE and 150 µg of LNG. One-year data were obtained from 48 volunteers. Results: The direction and

magnitude of the changes (increase or decrease) in most of the homeostatic variables were similar in both treatment

groups. The majority of changes of all investigated variables remained within the reference ranges of variation. The

procoagulatory variables increased to some extent from baseline to treatment cycle 13, while the anticoagulatory

variables slightly decreased. In particular, thrombin turnover measured by prothrombin fragments 1+2 increased

during treatment by 35% in the 20 µg of EE group and by 38% in the 30 µg of EE group. Statistically significant

differences between the two treatment groups were found only for TAT. For the profibrinolytic variables, plasminogen

was increased by 42% (20 µg of EE) and 49% (30 µg of EE). While the plasma levels of tPA antigen were reduced

during treatment, the levels of its activity were increased by 54% (20 µg of EE) and 20% (30 µg of EE). For PAI, both

antigen and activity were decreased, somewhat more pronounced with 20 µg of EE. D-Dimer remained virtually

unchanged. Finally, the median FbDP levels were elevated by 30% (20 µg of EE) and 38% (30 µg of EE).

(PubHealth.info Document ID: CONT1T 55-06)

PubHealth.info NOTE: The author(s) of this article titled, "A 1-year study to compare the hemostatic effects of oral

contraceptive containing 20 micrograms of ethinylestradiol and 100 micrograms of levonorgestrel with 30 micrograms

of ethinylestradiol and 100 micrograms of levonorgestrel.", is(are) Jespersen J; Endrikat J; Düsterberg B; Schmidt

W; Gerlinger C. The source of this article is "Contraception. 2005;72:98-104.". This article was published in 2005 in

English language(s). (PubHealth.info® Document ID: CONT1T 55-06. All rights reserved with PubHealth.info) PIN:

55

This article is peer-reviewed.

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