Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2005

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

A 1-year randomized study to evaluate the effects of a dose reduction in

oral contraceptives on lipids and carbohydrate metabolism: 20 micrograms

ethinyl estradiol combined with 100 micrograms levonorgestrel.

AUTHORS

Skouby SO; Endrikat J; Düsterberg B; Schmidt W; Gerlinger C

SOURCE

Contraception. 2005;71:111-117.

ABSTRACT

Objectives: To evaluate the impact on lipid and carbohydrate variables of a combined one-third ethinyl estradiol

(EE)/levonorgestrel (LNG) dose reduction in oral contraceptives. Methods: In an open-label, randomized study, a

dose-reduced oral contraceptive containing 20 µg EE and 100 µg LNG (20 EE/100 LNG) was compared with a

reference preparation containing 30 µg EE and 150 µg LNG (30 EE/150 LNG). One-year data from 48 volunteers were

obtained. Results: We found a decrease of HDL2 cholesterol and increases of low-density lipoprotein cholesterol,

very low-density lipoprotein cholesterol and total triglycerides in both treatment groups from baseline to the 13th

treatment cycle. Although for four of six variables, the changes in the 20 EE group were lower compared with the 30

EE group, none of the differences between the two treatments were statistically significant. The median values for

the fasting levels of insulin, C-peptide and free fatty acids slightly increased or remained unchanged while the

fasting glucose levels slightly decreased after 13 treatment cycles. While the glucose area under the curve (AUC) (0-

3 h) was similar in both groups during the OGTT, the insulin AUC(0-3 h) was less increased in the 20 EE/100 LNG

group compared with the 30 EE/150 LNG group. None of the differences between the treatment groups for any of the

carbohydrate metabolism variables were statistically significant at any time point. Both study treatments were safe

and well tolerated by the volunteers. Conclusion: Similar effects on the lipid and carbohydrate profiles were found for

both preparations. The balanced one-third EE dose reduction in this new oral contraceptive caused slightly lower,

but insignificant, changes in the lipid and carbohydrate variables compared with the reference treatment.

(PubHealth.info Document ID: CONT1T 54-06)

PubHealth.info NOTE: The author(s) of this article titled, "A 1-year randomized study to evaluate the effects of a dose

reduction in oral contraceptives on lipids and carbohydrate metabolism: 20 micrograms ethinyl estradiol combined

with 100 micrograms levonorgestrel.", is(are) Skouby SO; Endrikat J; Düsterberg B; Schmidt W; Gerlinger C. The

source of this article is "Contraception. 2005;71:111-117.". This article was published in 2005 in English

language(s). (PubHealth.info® Document ID: CONT1T 54-06. All rights reserved with PubHealth.info) PIN: 54

This article is peer-reviewed.

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