Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2004

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Efficacy of nonhormonal vaginal contraceptives from a hydrogel delivery

system.

AUTHORS

Saxena BB; Singh M; Gospin RM; Chu CC; Ledger WJ

SOURCE

Contraception. 2004;70:213-219.

ABSTRACT

This investigation describes the synthesis of a biodegradable hydrogel composed of a core surrounded by four

concentric sheaths containing dextran, copolymers of polylactide and e-caprolactone. The hydrogel was impregnated

with iron (II) D-gluconate dihydrate, which causes complete spermiostasis due to lipid peroxidation, ascorbic acid to

increase the viscosity of the cervical mucus and mixtures of polyamino and polycarboxylic acids to sustain vaginal

pH close to 4.5. The combined effects of the agents in the daily eluates of the hydrogel were efficacious up to 16

days, within 30 s, as shown by sperm penetration tests. For in vivo studies, rabbits were chosen as the experimental

model because they are easy to handle and the female is always in estrus. The anterior vagina of estrous female

rabbits was instilled with the hydrogel, and then inseminated with the semen from a fertile male. Postinsemination

flush from the female rabbits showed that all of the sperm were dead. These observations demonstrate the potential

for the development of a biocompatible, nonhormonal, intravaginal contraceptive device. (PubHealth.info Document

ID: CONT1T 539-06)

PubHealth.info NOTE: The author(s) of this article titled, "Efficacy of nonhormonal vaginal contraceptives from a

hydrogel delivery system.", is(are) Saxena BB; Singh M; Gospin RM; Chu CC; Ledger WJ. The source of this

article is "Contraception. 2004;70:213-219.". This article was published in 2004 in English language(s).

(PubHealth.info® Document ID: CONT1T 539-06. All rights reserved with PubHealth.info) PIN: 539

This article is peer-reviewed.

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