Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2004

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

The effect of hormonal contraception on genital tract shedding of HIV-1.

AUTHORS

Wang CC; McClelland RS; Overbaugh J; Reilly M; Panteleeff DD

SOURCE

AIDS. 2004 Jan 23;18(2):205-209.

ABSTRACT

A previous cross-sectional study reported that hormonal contraception may be associated with increased infectivity

in HIV-1 infected women. We conducted a prospective study to determine if cervical shedding of HIV-1 increased

after initiating hormonal contraception. Shedding of HIV-1 DNA (a marker of HIV-1 infected cells) and HIV-1 RNA

were measured before and after initiating hormonal contraception. HIV-1 seropositive women were recruited from a

Kenyan family planning clinic. At baseline, cervical secretions were collected for HIV-1 DNA and RNA assays in

women initiating hormonal contraception; follow-up samples were collected a median of 64 days later. One-hundred

and one women chose depot medroxyprogesterone (Depo), 53 chose low-dose oral contraceptives (OC), seven high-

dose OC, and 52 progesteroneonly OC. At follow-up, there was a significant increase in the prevalence of cervical

HIV-1 DNA detection [from 42% to 52%, odds ratio (OR), 1.62; 95% confidence interval (CI), 1.03-2.63) for all

hormonal contraception combined, and a trend for an increase for each individual type. Although the prevalence of

cervical HIV-1 RNA increased slightly (from 82% to 86%; OR, 1.56; 95% CI, 0.83-3.03), the concentration of cervical

HIV-1 RNA did not change significantly overall (from 2.81 to 2.84 log10 copies/swab; P = 0.77) or for individual

contraception types. A modest but significant increase in shedding of HIV-1 DNA but not of HIV-1 RNA was detected

after starting hormonal contraception. Our results may have important implications regarding the infectivity of women

using hormonal contraception, and highlight the need for epidemiologic studies of transmission rates from women

using and not using hormonal contraception. (PubHealth.info Document ID: CONT1T 533-06)

PubHealth.info NOTE: The author(s) of this article titled, "The effect of hormonal contraception on genital tract

shedding of HIV-1.", is(are) Wang CC; McClelland RS; Overbaugh J; Reilly M; Panteleeff DD. The source of this

article is "AIDS. 2004 Jan 23;18(2):205-209.". This article was published in 2004 in English language(s).

(PubHealth.info® Document ID: CONT1T 533-06. All rights reserved with PubHealth.info) PIN: 533

This article is peer-reviewed.

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